Chlorproguanil/dapsone

Chlorproguanil/dapsone
Combination of
Chlorproguanil	Antimalarial drug
Dapsone	Antibiotic
Legal status
Legal status	Withdrawn

Chlorproguanil/dapsone (sold commercially as Lapdap) was a fixed dose antimalarial combination containing chlorproguanil and dapsone,^[1] which act synergystically against malaria. The drug was withdrawn in 2008 following increasing evidence of toxicity in the form of haemolysis occurring in patients with G6PD deficiency.^[2]

References

↑ Lang T, Greenwood B (March 2003). "The development of Lapdap, an affordable new treatment for malaria". Lancet Infect Dis. 3 (3): 162–8. PMID 12614733. doi:10.1016/S1473-3099(03)00547-4.
↑ Luzzatto, L. (2010). "The rise and fall of the antimalarial Lapdap: A lesson in pharmacogenetics". The Lancet. 376 (9742): 739–741. PMID 20599264. doi:10.1016/S0140-6736(10)60396-0.

Antiparasitics – antiprotozoal agents – Chromalveolate antiparasitics (P01)

Alveo-
late

Apicom-
plexa

Conoidasida/
(Coccidiostats)

Cryptosporidiosis	thiazolides (nitazoxanide)
Isosporiasis	trimethoprim/sulfamethoxazole^#
Toxoplasmosis	pyrimethamine sulfadiazine

Aconoidasida

Malaria

Individual
agents

Hemozoin
inhibitors

Aminoquinolines	(4-): amodiaquine^# chloroquine^# hydroxychloroquine^# (8-): primaquine^# pamaquine^‡ tafenoquine^†
4-Methanolquinolines	mefloquine^# quinine^# quinidine
Other	lumefantrine + artemether^# halofantrine

Antifolates

DHFR inhibitors	pyrimethamine biguanides chlorproguanil proguanil^#
Sulfonamides	sulfadoxine sulfalene
Co-formulation	sulfadoxine/pyrimethamine (SP)^#

Sesquiterpene
lactones

Other

Combi-
nations

Fixed-dose (co-formulated) ACTs	artemether/lumefantrine^# arterolane/piperaquine artesunate/amodiaquine (ASAQ) artesunate/mefloquine (ASMQ) artesunate/pyronaridine dihydroartemisinin/piperaquine
Other combinations (not co-formulated)	artesunate/mefloquine artesunate/SP quinine/clindamycin quinine/doxycycline quinine/tetracycline

Babesiosis

clindamycin

Cilio-
phora

Balantidiasis: tetracycline

Hetero-
kont

Blastocystosis: metronidazole

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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