Chloride potassium symporter 4
SLC12A4 | |||||||
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Identifiers | |||||||
Aliases | SLC12A4, KCC1, Chloride potassium symporter 4, CTC-479C5.17, hKCC1, solute carrier family 12 member 4 | ||||||
External IDs | MGI: 1309465 HomoloGene: 21056 GeneCards: SLC12A4 | ||||||
Orthologs | |||||||
Species | Human | Mouse | |||||
Entrez | |||||||
Ensembl | |||||||
UniProt | |||||||
RefSeq (mRNA) | |||||||
RefSeq (protein) | |||||||
Location (UCSC) | Chr 16: 67.94 – 67.97 Mb | Chr 8: 105.94 – 105.97 Mb | |||||
PubMed search | [1] | [2] | |||||
Wikidata | |||||||
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Potassium-chloride transporter, member 4 is a chloride potassium symporter. It is encoded by the gene SLC12A4.[3]
See also
References
Further reading
- Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1.". Hum. Mol. Genet. 2 (10): 1589–95. PMID 8268911. doi:10.1093/hmg/2.10.1589.
- Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.". J. Biol. Chem. 271 (27): 16237–44. PMID 8663127. doi:10.1074/jbc.271.27.16237.
- Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.". Blood Cells Mol. Dis. 24 (1): 31–40. PMID 9516379. doi:10.1006/bcmd.1998.0168.
- Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.". Am. J. Physiol. 277 (5 Pt 1): C899–912. PMID 10564083.
- Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.". J. Biol. Chem. 276 (45): 41870–8. PMID 11551954. doi:10.1074/jbc.M107155200.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl− channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. PMID 12637262. doi:10.1152/ajpcell.00289.2002.
- Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. PMID 12902337. doi:10.1074/jbc.M308232200.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood. 103 (11): 4302–9. PMID 14976052. doi:10.1182/blood-2003-01-0107.
- Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K+–Cl− cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry (Amsterdam, Netherlands). 62 (2): 141–6. PMID 15039017. doi:10.1016/j.bioelechem.2003.07.005.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
- Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. PMID 15262997. doi:10.1074/jbc.M406706200.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
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