Calcium/cholecalciferol

Calcium/cholecalciferol
Combination of
Calcium	Mineral nutrient
Cholecalciferol	Vitamin
Clinical data
AHFS/Drugs.com	Multum Consumer Information
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	A12AX (WHO)
Legal status
Legal status	US: OTC

Calcium/cholecalciferol is a combination of a calcium salt (usually calcium carbonate) and vitamin D₃ (cholecalciferol), available under many brand names and in many forms such as chewable tablets, coated tablets, and effervescent tablets. It is used to prevent and treat lack of calcium and vitamin D in the elderly, as well as adjunctive therapy for osteoporosis.^[1]^[2]

Adverse effects and overdose

Possible side effects include gastrointestinal problems, for example nausea and constipation. If very high doses are taken, signs of hypercalcaemia (too high blood calcium levels) have been described, such as stomach pain, vomiting, thirst, and tiredness. Extreme or long-term or overdose can theoretically result in hypervitaminosis D, kidney stones, renal insufficiency and calcinosis.^[1]^[2]

Interactions

Calcium forms complexes with a number of pharmaceutical drugs, reducing their bioavailability; among them are tetracyclines, quinolone antibiotics, levothyroxine, and bisphosphonates, as well as iron, magnesium and zinc supplements. Vitamin D in usual doses has no relevant interactions.^[2]

References

1 2 Multum Consumer Information on calcium and vitamin D combinations.
1 2 3 Haberfeld, H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Cal-D-Vita-Kautabletten.

Mineral supplements (A12)

Major

Calcium	β-hydroxy-β-methylbutyrate carbonate chloride +cholecalciferol citrate glubionate glucoheptonate gluconate^# glycerylphosphate hydroxyapatite lactate gluconate lactate pangamate phosphate
Magnesium	aspartate chloride citrate gluconate glycinate lactate levulinate malate orotate oxide pidolate sulfate taurate
Phosphorus	adenosine triphosphate disodium hydroxyapatite monosodium phosphate
Potassium	bicarbonate bitartrate chloride citrate gluconate
Sodium	chloride sulfate
Sulfur	L-cysteine L-cystine L-glutathione L-methionine methylsulfonylmethane N-acetyl-L-cysteine R-α-lipoic acid S-adenosyl methionine taurine

Trace

Copper	gluconate
Iodine	potassium iodide
Iron	(II) fumarate (II) sulfate
Selenium	selenate selenite
Zinc	acetate L-aspartate L-carnosine gluconate oxide proteinate sulfate

Ultratrace

Chromium	(III) picolinate (III) chloride
Fluorine	fluoride^# monofluorophosphate
Lithium	aspartate carbonate orotate
Vanadium	(IV) sulfate

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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