CYP2W1
| CYP2W1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | CYP2W1, cytochrome P450 family 2 subfamily W member 1 | ||||||
| External IDs | MGI: 3616076 HomoloGene: 69239 GeneCards: CYP2W1 | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez | |||||||
| Ensembl | |||||||
| UniProt | |||||||
| RefSeq (mRNA) | |||||||
| RefSeq (protein) | |||||||
| Location (UCSC) | Chr 7: 0.98 – 0.99 Mb | Chr 5: 139.35 – 139.36 Mb | |||||
| PubMed search | [1] | [2] | |||||
| Wikidata | |||||||
| |||||||
CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[3]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[4] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504. - ↑ "Entrez Gene: CYP2W1".
External links
- Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. PMID 17998294. doi:10.1124/dmd.107.019141.
- Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. PMID 16677611. doi:10.1016/j.bbrc.2006.04.080.
- Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. PMID 16426568. doi:10.1016/j.bbrc.2005.12.200.
- Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. PMID 17979506. doi:10.2217/14622416.8.10.1315.
- Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. PMID 15128046. doi:10.1097/00008571-200401000-00001.
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