CTNND1

CTNND1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTNND1, CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), catenin delta 1
External IDsMGI: 105100 HomoloGene: 1017 GeneCards: CTNND1
Orthologs
SpeciesHumanMouse
Entrez

1500

12388

Ensembl

ENSG00000198561

ENSMUSG00000034101

UniProt

O60716

P30999

RefSeq (mRNA)

NM_001085448
NM_001085449
NM_001085450
NM_001085453
NM_007615

RefSeq (protein)

NP_001078917
NP_001078918
NP_001078919
NP_001078922
NP_031641

Location (UCSC)Chr 11: 57.75 – 57.82 MbChr 2: 84.6 – 84.65 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene.[3]

Function

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.[4]

Interactions

CTNND1 has been shown to interact with:

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM (October 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics. 31 (1): 127–9. PMID 8808291. doi:10.1006/geno.1996.0020.
  4. ↑ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1".
  5. 1 2 Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. PMID 9535896. doi:10.1074/jbc.273.15.9078.
  6. ↑ Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. PMID 11712088. doi:10.3892/ijmm.8.6.695.
  7. 1 2 3 Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M. "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. PMC 150740 Freely accessible. PMID 12640114. doi:10.1128/MCB.23.7.2287-2297.2003.
  8. ↑ Daniel JM, Reynolds AB (September 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. PMC 230726 Freely accessible. PMID 7651399. doi:10.1128/mcb.15.9.4819.
  9. ↑ Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB. "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. PMC 2173073 Freely accessible. PMID 12427869. doi:10.1083/jcb.200205115.
  10. ↑ Kinch MS, Clark GJ, Der CJ, Burridge K. "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. PMC 2199929 Freely accessible. PMID 7542250. doi:10.1083/jcb.130.2.461.
  11. ↑ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F. "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. PMC 2172904 Freely accessible. PMID 12707304. doi:10.1083/jcb.200303036.
  12. ↑ Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M. "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. PMC 2120395 Freely accessible. PMID 7876318. doi:10.1083/jcb.128.5.949.
  13. ↑ Ohkubo T, Ozawa M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. PMID 10409703. doi:10.1074/jbc.274.30.21409.
  14. ↑ Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. 116 (Pt 24): 4985–95. PMID 14625392. doi:10.1242/jcs.00815.
  15. ↑ Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. PMID 12604612. doi:10.1074/jbc.M211452200.
  16. ↑ Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. PMID 10321838. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1.
  17. 1 2 Martinez MC, Ochiishi T, Majewski M, Kosik KS. "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. PMC 2172717 Freely accessible. PMID 12835311. doi:10.1083/jcb.200211025.
  18. ↑ Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. PMID 11181067. doi:10.1006/bbrc.2001.4383.
  19. ↑ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG. "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. PMC 1618613 Freely accessible. PMID 15331416. doi:10.1016/S0002-9440(10)63354-8.
  20. ↑ Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8. PMID 10208590. doi:10.1097/00001756-199902250-00022.
  21. ↑ Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD (August 2000). "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. PMID 10835420. doi:10.1074/jbc.M001315200.
  22. ↑ Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (October 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. PMID 12370829. doi:10.1038/sj.onc.1205858.
  23. ↑ Zondag GC, Reynolds AB, Moolenaar WH (April 2000). "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. PMID 10753936. doi:10.1074/jbc.275.15.11264.
  24. ↑ Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. PMID 11855855. doi:10.1006/excr.2001.5436.
  25. ↑ Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell. Sci. 110 (17): 2065–77. PMID 9378757.
  26. ↑ Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. PMC 84161 Freely accessible. PMID 10207085. doi:10.1128/mcb.19.5.3614.

Further reading

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