CPD (gene)

CPD
Identifiers
AliasesCPD, GP180, carboxypeptidase D
External IDsMGI: 107265 HomoloGene: 999 GeneCards: CPD
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1362

12874

Ensembl

ENSG00000108582

ENSMUSG00000020841

UniProt

O75976

O89001

RefSeq (mRNA)

NM_001199775
NM_001304

NM_007754

RefSeq (protein)

NP_001186704
NP_001295

NP_031780

Location (UCSC)Chr 17: 30.38 – 30.47 MbChr 11: 76.78 – 76.85 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase D is an enzyme that in humans is encoded by the CPD gene.[3][4][5]

Function

The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities: the pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[5]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Riley DA, Tan F, Miletich DJ, Skidgel RA (May 1998). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics. 50 (1): 105–8. PMID 9628828. doi:10.1006/geno.1998.5295.
  4. ↑ Tan F, Rehli M, Krause SW, Skidgel RA (Oct 1997). "Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domains". The Biochemical Journal. 327 ( Pt 1) (Pt 1): 81–7. PMC 1218766 Freely accessible. PMID 9355738.
  5. 1 2 "Entrez Gene: CPD carboxypeptidase D".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138. 
  • McGwire GB, Tan F, Michel B, Rehli M, Skidgel RA (1997). "Identification of a membrane-bound carboxypeptidase as the mammalian homolog of duck gp180, a hepatitis B virus-binding protein". Life Sciences. 60 (10): 715–24. PMID 9064476. doi:10.1016/S0024-3205(96)00642-X. 
  • Varlamov O, Fricker LD (Apr 1998). "Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: localization to the trans-Golgi network and recycling from the cell surface". Journal of Cell Science. 111 ( Pt 7) (7): 877–85. PMID 9490632. 
  • Ishikawa T, Murakami K, Kido Y, Ohnishi S, Yazaki Y, Harada F, Kuroki K (Jul 1998). "Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme". Gene. 215 (2): 361–70. PMID 9714835. doi:10.1016/S0378-1119(98)00270-4. 
  • Reznik SE, Salafia CM, Lage JM, Fricker LD (Dec 1998). "Immunohistochemical localization of carboxypeptidases E and D in the human placenta and umbilical cord". The Journal of Histochemistry and Cytochemistry. 46 (12): 1359–68. PMID 9815277. doi:10.1177/002215549804601204. 
  • Hadkar V, Skidgel RA (May 2001). "Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium". Molecular Pharmacology. 59 (5): 1324–32. PMID 11306718. 
  • Fan X, Olson SJ, Blevins LS, Allen GS, Johnson MD (Nov 2002). "Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary". The Journal of Histochemistry and Cytochemistry. 50 (11): 1509–16. PMID 12417617. doi:10.1177/002215540205001111. 
  • Kalinina EV, Fricker LD (Mar 2003). "Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking". The Journal of Biological Chemistry. 278 (11): 9244–9. PMID 12643288. doi:10.1074/jbc.M209379200. 
  • Zhang H, Li XJ, Martin DB, Aebersold R (Jun 2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nature Biotechnology. 21 (6): 660–6. PMID 12754519. doi:10.1038/nbt827. 
  • O'Malley PG, Sangster SM, Abdelmagid SA, Bearne SL, Too CK (Sep 2005). "Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells". The Biochemical Journal. 390 (Pt 3): 665–73. PMC 1199659 Freely accessible. PMID 15918796. doi:10.1042/BJ20050025. 
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