COP9 constitutive photomorphogenic homolog subunit 5

COPS5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOPS5, CSN5, JAB1, MOV-34, SGN5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome subunit 5
External IDsMGI: 1349415 HomoloGene: 55992 GeneCards: COPS5
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10987

26754

Ensembl

ENSG00000121022

ENSMUSG00000025917

UniProt

Q92905

O35864

RefSeq (mRNA)

NM_006837

NM_001277101
NM_013715

RefSeq (protein)

NP_006828
NP_006828.2

NP_001264030
NP_038743

Location (UCSC)Chr 8: 67.04 – 67.08 MbChr 1: 10.02 – 10.04 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.[3]

Function

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.[3]

Interactions

COP9 constitutive photomorphogenic homolog subunit 5 has been shown to interact with Macrophage migration inhibitory factor,[4] GFER,[5] BCL3,[6] Ubiquitin carboxy-terminal hydrolase L1,[7] S100A7[8] and C-jun.[9]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)".
  4. ↑ Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J (November 2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature. 408 (6809): 211–6. PMID 11089976. doi:10.1038/35041591.
  5. ↑ Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F (January 2002). "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB J. 16 (1): 90–2. PMID 11709497. doi:10.1096/fj.01-0506fje.
  6. ↑ Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. PMID 10362352. doi:10.1038/sj.onc.1202717.
  7. ↑ Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J (May 2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene. 21 (19): 3003–10. PMID 12082530. doi:10.1038/sj.onc.1205390.
  8. ↑ Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC, Watson PH (April 2003). "Psoriasin interacts with Jab1 and influences breast cancer progression". Cancer Res. 63 (8): 1954–61. PMID 12702588.
  9. ↑ Claret FX, Hibi M, Dhut S, Toda T, Karin M (October 1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature. 383 (6599): 453–7. PMID 8837781. doi:10.1038/383453a0.

Further reading

  • Wolf DA, Zhou C, Wee S (2003). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. PMID 14647295. doi:10.1038/ncb1203-1029. 
  • Claret FX, Hibi M, Dhut S, Toda T, Karin M (1996). "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors". Nature. 383 (6599): 453–7. PMID 8837781. doi:10.1038/383453a0. 
  • Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW (1997). "Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly". J. Biol. Chem. 272 (43): 27042–52. PMID 9341143. doi:10.1074/jbc.272.43.27042. 
  • Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219. 
  • Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex". Curr. Biol. 8 (16): 919–22. PMID 9707402. doi:10.1016/S0960-9822(07)00372-7. 
  • Tomoda K, Kubota Y, Kato J (1999). "Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1". Nature. 398 (6723): 160–5. PMID 10086358. doi:10.1038/18230. 
  • Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. PMID 10362352. doi:10.1038/sj.onc.1202717. 
  • Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E, Loosfelt H (2000). "JAB1 interacts with both the progesterone receptor and SRC-1". J. Biol. Chem. 275 (12): 8540–8. PMID 10722692. doi:10.1074/jbc.275.12.8540. 
  • Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, Rogge L, Pardi R (2000). "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity". Nature. 404 (6778): 617–21. PMID 10766246. doi:10.1038/35007098. 
  • Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J (2000). "Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1". Nature. 408 (6809): 211–6. PMID 11089976. doi:10.1038/35041591. 
  • Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. PMC 145508 Freely accessible. PMID 11285227. doi:10.1093/emboj/20.7.1630. 
  • Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. PMID 11337588. doi:10.1126/science.1059780. 
  • Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N, Kato JY (2002). "The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex". J. Biol. Chem. 277 (3): 2302–10. PMID 11704659. doi:10.1074/jbc.M104431200. 
  • Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW (2002). "Jab1 interacts directly with HIF-1alpha and regulates its stability". J. Biol. Chem. 277 (1): 9–12. PMID 11707426. doi:10.1074/jbc.C100442200. 
  • Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F (2002). "Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway". FASEB J. 16 (1): 90–2. PMID 11709497. doi:10.1096/fj.01-0506fje. 
  • Dai YS, Cserjesi P (2002). "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer". J. Biol. Chem. 277 (15): 12604–12. PMID 11812799. doi:10.1074/jbc.M200283200. 
  • Wan M, Cao X, Wu Y, Bai S, Wu L, Shi X, Wang N, Cao X (2002). "Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation". EMBO Rep. 3 (2): 171–6. PMC 1083965 Freely accessible. PMID 11818334. doi:10.1093/embo-reports/kvf024. 
  • Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson PF, Hooper JE, Drabkin HA (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway". Oncogene. 21 (22): 3507–16. PMID 12032852. doi:10.1038/sj.onc.1205437. 
  • Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J (2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene. 21 (19): 3003–10. PMID 12082530. doi:10.1038/sj.onc.1205390. 
  • Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ (2002). "Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1". J. Biol. Chem. 277 (36): 32413–6. PMID 12119282. doi:10.1074/jbc.C200311200. 
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