COPB1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
5A1U, 5A1V, 5A1W, 5A1X, 5A1Y

Identifiers

Aliases

COPB1, COPB, coatomer protein complex subunit beta 1

External IDs

MGI: 1917599 HomoloGene: 5664 GeneCards: COPB1

Gene ontology
Molecular function	• structural molecule activity • protein binding
Cellular component	• Golgi apparatus • membrane • intracellular membrane-bounded organelle • Golgi membrane • COPI-coated vesicle membrane • transport vesicle • Golgi-associated vesicle • membrane coat • cytoplasmic vesicle • COPI-coated vesicle • endoplasmic reticulum-Golgi intermediate compartment • endoplasmic reticulum membrane • cytoplasm • cytosol • plasma membrane • COPI vesicle coat • secretory granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane
Biological process	• protein transport • intracellular protein transport • viral process • vesicle-mediated transport • ER to Golgi vesicle-mediated transport • retrograde vesicle-mediated transport, Golgi to ER • intra-Golgi vesicle-mediated transport • neutrophil degranulation • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1315


70349

Ensembl


ENSG00000129083


ENSMUSG00000030754

UniProt


P53618


Q9JIF7

RefSeq (mRNA)


NM_016451 NM_001144061 NM_001144062


NM_033370

RefSeq (protein)


NP_001137533 NP_001137534 NP_057535


NP_203534

Location (UCSC)

Chr 11: 14.44 – 14.5 Mb

Chr 7: 114.22 – 114.25 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Coatomer subunit beta is a protein that in humans is encoded by the COPB1 gene.^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Benichou S, Bomsel M, Bodeus M, Durand H, Doute M, Letourneur F, Camonis J, Benarous R (Dec 1994). "Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic". J Biol Chem. 269 (48): 30073–6. PMID 7982906.

External links

Human COPB1 genome location and COPB1 gene details page in the UCSC Genome Browser.

Benichou S, Liu LX, Erdtmann L, et al. (1997). "Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein". Res. Virol. 148 (1): 71–3. PMID 9017839. doi:10.1016/S0923-2516(97)81918-8.
Geyer M, Fackler OT, Peterlin BM (2001). "Structure–function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. PMC 1083955 . PMID 11463741. doi:10.1093/embo-reports/kve141.
Duden R, Griffiths G, Frank R, et al. (1991). "Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin". Cell. 64 (3): 649–65. PMID 1840503. doi:10.1016/0092-8674(91)90248-W.
Waters MG, Serafini T, Rothman JE (1991). "'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles". Nature. 349 (6306): 248–51. PMID 1898986. doi:10.1038/349248a0.
Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature. 364 (6439): 732–4. PMID 8355790. doi:10.1038/364732a0.
Aniento F, Gu F, Parton RG, Gruenberg J (1996). "An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes". J. Cell Biol. 133 (1): 29–41. PMC 2120778 . PMID 8601610. doi:10.1083/jcb.133.1.29.
Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. 271 (48): 30725–30. PMID 8940050. doi:10.1074/jbc.271.48.30725.
Hansen K, Rönnstrand L, Rorsman C, et al. (1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. Commun. 235 (3): 455–60. PMID 9207175. doi:10.1006/bbrc.1997.6821.
Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: Functional characterization of a β/δ-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. PMC 19276 . PMID 9482852. doi:10.1073/pnas.95.5.2140.
Piguet V, Gu F, Foti M, et al. (1999). "Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes". Cell. 97 (1): 63–73. PMID 10199403. doi:10.1016/S0092-8674(00)80715-1.
Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23". J. Biol. Chem. 274 (20): 14198–203. PMID 10318838. doi:10.1074/jbc.274.20.14198.
Fischer KD, Helms JB, Zhao L, Wieland FT (2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles". Methods. 20 (4): 455–64. PMID 10720466. doi:10.1006/meth.2000.0958.
Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. PMID 10903204. doi:10.1126/science.289.5478.444.
Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. PMC 306616 . PMID 10921873. doi:10.1093/emboj/19.15.3905.
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 Bind Coatomer and Inhibit COPI Association with Golgi Membranes and Intracellular Transport". Mol. Biol. Cell. 11 (9): 3155–68. PMC 14982 . PMID 10982407. doi:10.1091/mbc.11.9.3155.
Futatsumori M, Kasai K, Takatsu H, et al. (2001). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. PMID 11056392. doi:10.1093/oxfordjournals.jbchem.a022817.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE	Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Synaptotagmin

SYT1
SYT2
SYT3
SYT4
SYT5
SYT6
SYT7
SYT8
SYT9
SYT10
SYT11
SYT12
SYT13
SYT14
SYT15
SYT16
SYT17

Other

Small GTPase: RAB3A

COPI

Coatomer
- COPA
- COPB1
- COPB2
- COPD/Archain
- COPE
- COPG
- COPG2
- COPZ1
- COPZ2

Small GTPase: ARF

COPII

Coatomer
- SEC23A/SEC24A
- SEC13/SEC31

Small GTPase: SAR1A

RME/Clathrin

CLTA
CLTB
CLTC

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:	DTNBP1 BLOC153
BLOC-2:	HPS3 HPS5 HPS6
BLOC-3:	HPS1 HPS4
Coats:	Retromer TIP47

Small GTPase

Dynamin
- DNM1
- DNM2
- DNM3

Other

Sorting nexins

SYNRG

See also vesicular transport protein disorders

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COPB1

References

External links

Further reading