CNOT7

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2D5R, 4GMJ

Identifiers

Aliases

CNOT7, CAF1, Caf1a, hCAF-1, CAF-1, CCR4-NOT transcription complex subunit 7

External IDs

MGI: 1298230 HomoloGene: 49011 GeneCards: CNOT7

Gene ontology
Molecular function	• nuclease activity • nucleic acid binding • exoribonuclease activity • protein binding • 3'-5'-exoribonuclease activity • signal transducer activity • poly(A)-specific ribonuclease activity • exonuclease activity • RNA binding • transcription factor activity, sequence-specific DNA binding • hydrolase activity • metal ion binding • transcriptional repressor activity, RNA polymerase II transcription factor binding • transcription factor binding
Cellular component	• nucleus • CCR4-NOT complex • cytosol • membrane • nuclear body • P-body • cytoplasm • nuclear speck • CCR4-NOT core complex • host cell PML body
Biological process	• negative regulation of cell proliferation • negative regulation of gene expression • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • deadenylation-dependent decapping of nuclear-transcribed mRNA • nucleic acid phosphodiester bond hydrolysis • cytoplasmic mRNA processing body assembly • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • regulation of transcription, DNA-templated • positive regulation of cell proliferation • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • positive regulation of transcription from RNA polymerase II promoter • positive regulation of mRNA catabolic process • gene silencing by miRNA • regulation of translation • carbohydrate metabolic process • nuclear-transcribed mRNA poly(A) tail shortening • signal transduction • gene silencing by RNA • transcription, DNA-templated • RNA phosphodiester bond hydrolysis, exonucleolytic • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • negative regulation of transcription from RNA polymerase II promoter • regulation of tyrosine phosphorylation of STAT protein • positive regulation of viral genome replication • negative regulation of transcription, DNA-templated • defense response to virus • negative regulation of type I interferon-mediated signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


29883


18983

Ensembl


ENSG00000198791


ENSMUSG00000031601

UniProt


Q9UIV1


Q60809

RefSeq (mRNA)

NM_013354 NM_054026 NM_001322087 NM_001322088 NM_001322089
NM_001322090 NM_001322091 NM_001322092 NM_001322093 NM_001322094 NM_001322095 NM_001322096 NM_001322097 NM_001322098 NM_001322099 NM_001322100


NM_001271542 NM_001271543 NM_011135

RefSeq (protein)

NP_001309016 NP_001309017 NP_001309018 NP_001309019 NP_001309020
NP_001309021 NP_001309022 NP_001309023 NP_001309024 NP_001309025 NP_001309026 NP_001309027 NP_001309028 NP_001309029 NP_037486 NP_473367


NP_001258471 NP_001258472 NP_035265

Location (UCSC)

Chr 8: 17.22 – 17.25 Mb

Chr 8: 40.49 – 40.52 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene.^[3]^[4]^[5]^[6]

Function

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[6]

Interactions

CNOT7 has been shown to interact with:

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. PMC 102560 . PMID 10637334. doi:10.1093/nar/28.3.809.
↑ Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. PMID 1538749. doi:10.1038/355632a0.
↑ Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell. Sci. 120 (Pt 4): 638–47. PMID 17264152. doi:10.1242/jcs.03357.
1 2 "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7".
↑ Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 ( Pt 2): 471–81. PMC 1219893 . PMID 9820826.
↑ Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. PMID 11136725. doi:10.1074/jbc.M008201200.
1 2 Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. 21 (23): 3135–48. PMC 2081979 . PMID 18056425. doi:10.1101/gad.1597707.
1 2 Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. PMID 10602502. doi:10.1038/sj.onc.1203193.

External links

Human CNOT7 genome location and CNOT7 gene details page in the UCSC Genome Browser.

Draper MP, Salvadore C, Denis CL (1995). "Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex". Mol. Cell. Biol. 15 (7): 3487–95. PMC 230585 . PMID 7791755.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549. doi:10.1101/gr.6.9.807.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Rouault JP, Prévôt D, Berthet C, Birot AM, Billaud M, Magaud JP, Corbo L (1998). "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex". J. Biol. Chem. 273 (35): 22563–9. PMID 9712883. doi:10.1074/jbc.273.35.22563.
Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 ( Pt 2) (2): 471–81. PMC 1219893 . PMID 9820826.
Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. PMID 10602502. doi:10.1038/sj.onc.1203193.
Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. PMID 11136725. doi:10.1074/jbc.M008201200.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. PMID 11429045. doi:10.1111/j.1349-7006.2001.tb01135.x.
Flanagan J, Healey S, Young J, Whitehall V, Chenevix-Trench G (2003). "Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer". Int. J. Cancer. 106 (4): 505–9. PMID 12845644. doi:10.1002/ijc.11264.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.

PDB gallery

2d5r: Crystal Structure of a Tob-hCaf1 Complex

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CNOT7

Function

Interactions

References

External links

Further reading