CNKSR1

CNKSR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNKSR1, CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDsMGI: 2670958 HomoloGene: 4604 GeneCards: CNKSR1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10256

194231

Ensembl

ENSG00000142675

ENSMUSG00000028841

UniProt

Q969H4

A2A9K7

RefSeq (mRNA)

NM_001297647
NM_001297648
NM_006314

NM_001081047

RefSeq (protein)

NP_001284576
NP_001284577
NP_006305

NP_001074516

Location (UCSC)Chr 1: 26.18 – 26.19 MbChr 4: 134.23 – 134.24 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.[3][4]

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.[4]

Interactions

CNKSR1 has been shown to interact with RhoD[5] and RASSF1.[6]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. PMID 9814705. doi:10.1016/S0092-8674(00)81766-3.
  4. 1 2 "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".
  5. ↑ Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. PMC 344169 Freely accessible. PMID 14749388. doi:10.1128/MCB.24.4.1736-1746.2004.
  6. ↑ Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. PMID 15075335. doi:10.1074/jbc.M401699200.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3. 
  • Therrien M, Wong AM, Kwan E, Rubin GM (1999). "Functional analysis of CNK in RAS signaling". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13259–63. PMC 23935 Freely accessible. PMID 10557308. doi:10.1073/pnas.96.23.13259. 
  • Hartsough MT, Morrison DK, Salerno M, Palmieri D, Ouatas T, Mair M, Patrick J, Steeg PS (2002). "Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway". J. Biol. Chem. 277 (35): 32389–99. PMID 12105213. doi:10.1074/jbc.M203115200. 
  • Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. PMID 14724641. doi:10.1038/nature02237. 
  • Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. PMC 344169 Freely accessible. PMID 14749388. doi:10.1128/MCB.24.4.1736-1746.2004. 
  • Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. PMID 15075335. doi:10.1074/jbc.M401699200. 
  • Jaffe AB, Hall A, Schmidt A (2005). "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol. 15 (5): 405–12. PMID 15753034. doi:10.1016/j.cub.2004.12.082. 
  • Ziogas A, Moelling K, Radziwill G (2005). "CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation". J. Biol. Chem. 280 (25): 24205–11. PMID 15845549. doi:10.1074/jbc.M413327200. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Fritz RD, Radziwill G (2006). "The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor". Biochem. Biophys. Res. Commun. 338 (4): 1906–12. PMID 16289034. doi:10.1016/j.bbrc.2005.10.168. 
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240. 


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