CLOVES syndrome
| CLOVES syndrome | |
|---|---|
| Synonyms | Congenital lipomatous overgrowth-vascular malformation-epidermal nevi-spinal anomaly syndrome, Congenital lipomatous overgrowth-vascular malformation-epidermal nevi-skeletal anomaly syndrome |
 | |
| Mutations affecting PI3kinase are involved in the cause of this condition | |
| Classification and external resources | |
| ICD-10 | Q87.3 |
| OMIM | 612918 |
| Orphanet | 140944 |
CLOVES syndrome is an extremely rare overgrowth syndrome, with complex vascular anomalies. CLOVES syndrome affects people with various symptoms, ranging from mild fatty soft-tissue tumors to vascular malformations encompassing the spine or internal organs. CLOVES syndrome is closely linked to other overgrowth disorders like proteus syndrome, Klippel–Trénaunay syndrome, Sturge–Weber syndrome, and hemihypertrophy, to name a few.
'CLOVES' is an acronym for:[1][2]
- C is for congenital.
- L is for lipomatous, which means pertaining to or resembling a benign tumor made up of mature fat cells. Most CLOVES patients present with a soft fatty mass at birth, often visible on one or both sides of the back, legs and/or abdomen.
- O is for overgrowth, because there is an abnormal increase in the size of the body or a body part that is often noted at birth. Patients with CLOVES may have affected areas of their bodies that grow faster than in other people. Overgrowth of extremities (usually arms or legs) is seen, with large wide hands or feet, large fingers or toes, wide space between fingers, and asymmetry of body parts.
- V is for vascular malformations, which are blood vessel abnormalies. Patients with CLOVES have different venous, capillary, and lymphatic channels - typically capillary, venous and lymphatic malformations are known as "slow flow" lesions. Some patients with CLOVES have combined lesions (which are fast flow) and some have aggressive vascular malformation known as arteriovenous malformations (AVM). The effect of a vascular malformation varies per patient based on the type, size, and location of the malformation, and symptoms can vary.
- E is for Epidermal naevi, which are sharply-circumscribed chronic lesions of the skin, and benign. These are often flesh-colored, raised or warty.
- S is for Spinal/Skeletal Anomalies or scoliosis. Some patients with CLOVES have tethered spinal cord, vascular malformations in or around their spines, and other spinal differences. High-flow aggressive spinal lesions (like AVM) can cause serious neurological deficits/paralysis.
The syndrome was first recognised by Saap and colleagues who recognised the spectrum of symptoms from a set of seven patients.[3] In this initial description the syndrome is named CLOVE syndrome. It is believed that the first description of a case of CLOVES syndrome was written by Hermann Friedberg, a German physician, in 1867.[4][5]
Causes
Somatic mutations in the PIK3CA have been identified as a cause of CLOVES syndrome.[6] PIK3CA is a protein involved in the PI3K-AKT signalling pathway. Mutations in other parts of this pathway cause other overgrowth syndromes including proteus syndrome and hemimegaencephaly.[6]
References
- ↑ "CLOVES Syndrome". clovessyndrome.org.
- ↑ Boston Childrens Hospital 2013. "CLOVES Syndrome - Boston Children's Hospital". childrenshospital.org.
- ↑ Sapp JC, Turner JT, van de Kamp JM, van Dijk FS, Lowry RB, Biesecker LG (2007). "Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients". Am. J. Med. Genet. A. 143A (24): 2944–58. PMID 17963221. doi:10.1002/ajmg.a.32023.
- ↑ "CLOVES Syndrome". National Organization for Rare Diseases. Archived from the original on April 2, 2015. Retrieved 24 March 2015.
- ↑ Alomari, AI; Thiex, R; Mulliken, JB (October 2010). "Hermann Friedberg's case report: an early description of CLOVES syndrome". Clinical Genetics. 78 (4): 342–347. doi:10.1111/j.1399-0004.2010.01479.x.
- 1 2 Kurek KC, Luks VL, Ayturk UM, Alomari AI, Fishman SJ, Spencer SA, Mulliken JB, Bowen ME, Yamamoto GL, Kozakewich HP, Warman ML (2012). "Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome". Am. J. Hum. Genet. 90 (6): 1108–15. PMC 3370283
. PMID 22658544. doi:10.1016/j.ajhg.2012.05.006.
External links
- CLOVES Syndrome Community - support group based in West Kennebunk, Maine, US