CLCA4
| CLCA4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | CLCA4, CaCC, CaCC2, chloride channel accessory 4 | ||||||
| External IDs | MGI: 2139790 HomoloGene: 40808 GeneCards: CLCA4 | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez | |||||||
| Ensembl | |||||||
| UniProt | |||||||
| RefSeq (mRNA) | |||||||
| RefSeq (protein) | |||||||
| Location (UCSC) | Chr 1: 86.55 – 86.58 Mb | Chr 3: 144.91 – 144.93 Mb | |||||
| PubMed search | [1] | [2] | |||||
| Wikidata | |||||||
| |||||||
Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.[3] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[4]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. PMID 10437792. doi:10.1016/S0014-5793(99)00891-1.
- ↑ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels.". Proteins. 63 (3): 424–39. PMID 16470849. doi:10.1002/prot.20887.
Further reading
- Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. PMC 18318
. PMID 10758170. doi:10.1073/pnas.090521697. - Ritzka M, Stanke F, Jansen S, et al. (2004). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.". Hum. Genet. 115 (6): 483–91. PMID 15490240. doi:10.1007/s00439-004-1190-y.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. PMC 403697 . PMID 12975309. doi:10.1101/gr.1293003.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2000). "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. PMID 11071307. doi:10.1046/j.1440-1681.2000.03358.x.
External links
- CLCA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CLCA4 genome location and CLCA4 gene details page in the UCSC Genome Browser.
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