CKM (gene)

CKM

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1I0E

Identifiers

Aliases

CKM, CKMM, M-CK, creatine kinase, M-type

External IDs

MGI: 88413 HomoloGene: 20432 GeneCards: CKM

Gene ontology
Molecular function	• transferase activity • creatine kinase activity • transferase activity, transferring phosphorus-containing groups • nucleotide binding • catalytic activity • protein binding • ATP binding • kinase activity
Cellular component	• cytoplasm • cytosol
Biological process	• creatine metabolic process • phosphocreatine biosynthetic process • phosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1158


12715

Ensembl


ENSG00000104879


ENSMUSG00000030399

UniProt


P06732


P07310

RefSeq (mRNA)


NM_001824


NM_007710

RefSeq (protein)


NP_001815


NP_031736

Location (UCSC)

Chr 19: 45.31 – 45.32 Mb

Chr 7: 19.4 – 19.42 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

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Creatine kinase, muscle also known as CKM is a creatine kinase that in humans is encoded by the CKM gene.^[3]

Structure

In the figure to the right, the crystal structure of the muscle-type M-CK monomer is shown. In vivo, two such monomers arrange symmetrically to form the active MM-CK enzyme.

Function

The protein encoded by this gene is a cytoplasmic enzyme involved in cellular energy homeostasis. The encoded protein reversibly catalyzes the transfer of "energy-rich" phosphate between ATP and creatine and between phospho-creatine and ADP. Its functional entity is a MM-CK homodimer in striated (sarcomeric) skeletal and cardiac muscle.

Clinical significance

In heart, in addition to the MM-CK homodimer, also the heterodimer MB-CK consisting of one muscle (M-CK) and one brain-type (B-CK) subunit is expressed. The latter may be an important serum marker for myocardial infarction, if released from damaged myocardial cells into the blood where it can be detected by clinical chemistry.

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (November 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. PMC 347173 . PMID 6959139. doi:10.1073/pnas.79.21.6589.

Zhao TJ, Yan YB, Liu Y, Zhou HM (2007). "The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase.". J. Biol. Chem. 282 (16): 12022–9. PMID 17303563. doi:10.1074/jbc.M610363200.
Yamin C, Amir O, Sagiv M, et al. (2007). "ACE ID genotype affects blood creatine kinase response to eccentric exercise.". J. Appl. Physiol. 103 (6): 2057–61. PMID 17885020. doi:10.1152/japplphysiol.00867.2007.
Warren GL, O'farrell L, Rogers KR, et al. (2006). "CK-MM autoantibodies: prevalence, immune complexes, and effect on CK clearance.". Muscle Nerve. 34 (3): 335–46. PMID 16810680. doi:10.1002/mus.20594.
Hemmer W, Wallimann T (1993). "Functional aspects of creatine kinase in brain.". Dev. Neurosci. 15 (3-5): 249–60. PMID 7805577. doi:10.1159/000111342.
Vikenes K, Andersen KS, Melberg T, et al. (2009). "Long-term prognostic value of creatine kinase-myocardial band mass after cardiac surgery in low-risk patients with stable angina.". Cardiology. 113 (2): 122–31. PMID 19039220. doi:10.1159/000177949.
Muniesa CA, González-Freire M, Santiago C, et al. (2008). "World-class performance in lightweight rowing: Is it genetically influenced? A comparison with cyclists, runners and non-athletes.". Br J Sports Med. 44 (12): HASH(0x2edd350). PMID 18801770. doi:10.1136/bjsm.2008.051680.
Wyss M, Kaddurah-Daouk R (2000). "Creatine and creatinine metabolism.". Physiol. Rev. 80 (3): 1107–213. PMID 10893433.
Finsterer J, Stöllberger C, Krugluger W (2008). "Significance of CK-elevation in noncompaction with regard to cardiac and neuromuscular disease.". Int. J. Cardiol. 130 (2): 174–9. PMID 18055044. doi:10.1016/j.ijcard.2007.08.038.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork.". Exp. Eye Res. 82 (6): 1046–52. PMID 16289162. doi:10.1016/j.exer.2005.09.016.
Heled Y, Bloom MS, Wu TJ, et al. (2007). "CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise.". J. Appl. Physiol. 103 (2): 504–10. PMID 17478608. doi:10.1152/japplphysiol.00081.2007.
Kelley WE, Lockwood CM, Cervelli DR, et al. (2009). "Cardiovascular disease testing on the Dimension Vista system: biomarkers of acute coronary syndromes.". Clin. Biochem. 42 (13-14): 1444–51. PMID 19523464. doi:10.1016/j.clinbiochem.2009.05.020.
Wang PF, Flynn AJ, Naor MM, et al. (2006). "Exploring the role of the active site cysteine in human muscle creatine kinase.". Biochemistry. 45 (38): 11464–72. PMC 2556515 . PMID 16981706. doi:10.1021/bi0607002.
Eeg-Olofsson O, Kalimo H, Eeg-Olofsson KE, et al. (2008). "Duchenne muscular dystrophy and idiopathic hyperCKemia in the same family.". Eur. J. Paediatr. Neurol. 12 (5): 404–7. PMID 18833644. doi:10.1016/j.ejpn.2007.10.014.
Santiago C, Ruiz JR, Muniesa CA, et al. (2009). "Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing.". Scand J Med Sci Sports. 20 (1): HASH(0x17274b0). PMID 19422651. doi:10.1111/j.1600-0838.2009.00943.x.
Sakha K, Samadi M, Rezamand A (2008). "Cardiac involvement of major thalassemia and evaluation of total serum creatine kinase and creatine kinase-mB isoenzyme and cardiac troponinI in these patients.". Pak. J. Biol. Sci. 11 (7): 1059–62. PMID 18810980. doi:10.3923/pjbs.2008.1059.1062.
Zhou DQ, Hu Y, Liu G, et al. (2006). "Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme.". Br J Sports Med. 40 (12): 988–91. PMC 2577470 . PMID 17000714. doi:10.1136/bjsm.2006.029744.
Koyama S, Hata S, Witt CC, et al. (2008). "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.". J. Mol. Biol. 376 (5): 1224–36. PMID 18222470. doi:10.1016/j.jmb.2007.11.049.
Li S, Bai JH, Park YD, Zhou HM (2006). "Capture of monomeric refolding intermediate of human muscle creatine kinase.". Protein Sci. 15 (1): 171–81. PMC 2242377 . PMID 16373479. doi:10.1110/ps.051738406.
Kim HJ, Lee YH, Kim CK (2009). "Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race.". Eur. J. Appl. Physiol. 105 (5): 765–70. PMID 19125286. doi:10.1007/s00421-008-0961-x.
Wallimann T, Hemmer W (1994). "Creatine kinase in non-muscle tissues and cells.". Mol. Cell. Biochem. 133–134: 193–220. PMID 7808454. doi:10.1007/BF01267955.

External links

Creatine Kinase, MM Form at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CKM genome location and CKM gene details page in the UCSC Genome Browser.

PDB gallery

2crk: MUSCLE CREATINE KINASE

1u6r: Transition state analog complex of muscle creatine kinase (R134K) mutant

1i0e: CRYSTAL STRUCTURE OF CREATINE KINASE FROM HUMAN MUSCLE

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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