CHRNA5
Neuronal acetylcholine receptor subunit alpha-5, also known as nAChRα5, is a protein that in humans is encoded by the CHRNA5 gene.[3][4] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).
Function
Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.[4]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
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Nicotine Activity on Dopaminergic Neurons edit
- ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. PMID 2004777. doi:10.1016/0888-7543(91)90253-B.
- 1 2 "Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5".
Further reading
- Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 147: 1–46. ISBN 978-3-540-01365-5. PMID 12783266. doi:10.1007/s10254-003-0005-1.
- Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. PMID 1505988. doi:10.1016/0888-7543(92)90008-G.
- Chini B, Clementi F, Hukovic N, Sher E (1992). "Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1572–6. PMC 48494
. PMID 1542648. doi:10.1073/pnas.89.5.1572. - Raimondi E, Rubboli F, Moralli D, et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics. 12 (4): 849–50. PMID 1572664. doi:10.1016/0888-7543(92)90324-L.
- Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. PMID 8906617. doi:10.1007/BF02736842.
- Groot Kormelink PJ, Luyten WH (1997). "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. PMID 9009220. doi:10.1016/S0014-5793(96)01383-X.
- Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand). 43 (3): 433–42. PMID 9193799.
- Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998). "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. PMID 9655874.
- Lentz TL (2000). "Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits". Biochem. Biophys. Res. Commun. 268 (2): 480–4. PMID 10679230. doi:10.1006/bbrc.2000.2155.
- Groot-Kormelink PJ, Boorman JP, Sivilotti LG (2001). "Formation of functional α3β4α5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–96. PMC 1573006 . PMID 11606319. doi:10.1038/sj.bjp.0704313.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Soldà G, Boi S, Duga S, et al. (2005). "In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs". Gene. 345 (2): 155–64. PMID 15716100. doi:10.1016/j.gene.2004.12.005.
External links
- CHRNA5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CHRNA5 genome location and CHRNA5 gene details page in the UCSC Genome Browser.
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