CFHR4

CFHR4

Identifiers

CFHR4, CFHL4, FHR-4, FHR4, complement factor H related 4

External IDs

HomoloGene: 136449 GeneCards: CFHR4

Gene ontology
Molecular function	• lipid transporter activity
Cellular component	• extracellular region
Biological process	• lipid transport • regulation of complement activation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


10877


n/a


ENSG00000134365


n/a


Q92496


n/a

RefSeq (mRNA)


NM_001201550 NM_001201551 NM_006684


n/a

RefSeq (protein)


NP_001188479 NP_001188480 NP_006675


n/a

Location (UCSC)

Chr 1: 196.85 – 196.92 Mb

n/a

PubMed search

^[1]

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View/Edit Human

Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene.^[2]^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ Skerka C, Hellwage J, Weber W, Tilkorn A, Buck F, Marti T, Kampen E, Beisiegel U, Zipfel PF (Apr 1997). "The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins". J Biol Chem. 272 (9): 5627–34. PMID 9038172. doi:10.1074/jbc.272.9.5627.
↑ Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H-related genes". Immunogenetics. 49 (6): 549–52. PMID 10380701. doi:10.1007/s002510050534.
↑ "Entrez Gene: CFHR4 complement factor H-related 4".

Further reading

Hageman GS, Hancox LS, Taiber AJ, et al. (2007). "Extended Haplotypes in the Complement Factor H (CFH) and CFH-related (CFHR) Family of Genes that Protect against Age-related Macular Degeneration: Identification, Ethnic Distribution and Evolutionary Implications". Ann. Med. 38 (8): 592–604. PMC 1905836 . PMID 17438673. doi:10.1080/07853890601097030.
Józsi M, Richter H, Löschmann I, et al. (2005). "FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene". Eur. J. Hum. Genet. 13 (3): 321–9. PMID 15562282. doi:10.1038/sj.ejhg.5201324.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hellwage J, Jokiranta TS, Koistinen V, et al. (2000). "Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin". FEBS Lett. 462 (3): 345–52. PMID 10622723. doi:10.1016/S0014-5793(99)01554-9.
Hellwage J, Skerka C, Zipfel PF (1998). "Biochemical and functional characterization of the factor-H-related protein 4 (FHR-4)". Immunopharmacology. 38 (1–2): 149–57. PMID 9476126. doi:10.1016/S0162-3109(97)00075-1.

External links

GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
OMIM entries on Atypical Hemolytic-Uremic Syndrome
Human CFHR4 genome location and CFHR4 gene details page in the UCSC Genome Browser.

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