Centrin 2
Centrin-2 is a protein that in humans is encoded by the CETN2 gene.[3][4][5] It belongs to the centrin family of proteins.
Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.[5]
Interactions
CETN2 has been shown to interact with XPC[6] and SFI1.[7]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Tanaka T, Okui K, Nakamura Y (May 1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization". Genomics. 24 (3): 609–10. PMID 7713520.
- ↑ Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions". Mamm Genome. 6 (11): 802–4. PMID 8597638. doi:10.1007/BF00539008.
- 1 2 "Entrez Gene: CETN2 centrin, EF-hand protein, 2".
- ↑ Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. United States. 276 (22): 18665–72. ISSN 0021-9258. PMID 11279143. doi:10.1074/jbc.M100855200.
- ↑ Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.". Journal of Molecular Biology. 395 (1): 191–204. PMID 19857500. doi:10.1016/j.jmb.2009.10.041.
External links
- Human CETN2 genome location and CETN2 gene details page in the UCSC Genome Browser.
Further reading
- Lee VD, Huang B (1994). "Molecular cloning and centrosomal localization of human caltractin.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11039–43. PMC 47917
. PMID 8248209. doi:10.1073/pnas.90.23.11039. - Wolfrum U, Salisbury JL (1998). "Expression of centrin isoforms in the mammalian retina.". Exp. Cell Res. 242 (1): 10–7. PMID 9665797. doi:10.1006/excr.1998.4038.
- Durussel I, Blouquit Y, Middendorp S, et al. (2000). "Cation- and peptide-binding properties of human centrin 2.". FEBS Lett. 472 (2-3): 208–12. PMID 10788612. doi:10.1016/S0014-5793(00)01452-6.
- Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.". Genome Res. 10 (6): 758–75. PMC 310879 . PMID 10854409. doi:10.1101/gr.10.6.758.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
- Araki M, Masutani C, Takemura M, et al. (2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.". J. Biol. Chem. 276 (22): 18665–72. PMID 11279143. doi:10.1074/jbc.M100855200.
- Salisbury JL, Suino KM, Busby R, Springett M (2003). "Centrin-2 is required for centriole duplication in mammalian cells.". Curr. Biol. 12 (15): 1287–92. PMID 12176356. doi:10.1016/S0960-9822(02)01019-9.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Matei E, Miron S, Blouquit Y, et al. (2003). "C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain.". Biochemistry. 42 (6): 1439–50. PMID 12578356. doi:10.1021/bi0269714.
- Gavet O, Alvarez C, Gaspar P, Bornens M (2004). "Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells.". Mol. Biol. Cell. 14 (5): 1818–34. PMC 165080 . PMID 12802058. doi:10.1091/mbc.E02-11-0709.
- Popescu A, Miron S, Blouquit Y, et al. (2003). "Xeroderma pigmentosum group C protein possesses a high affinity binding site to human centrin 2 and calmodulin.". J. Biol. Chem. 278 (41): 40252–61. PMID 12890685. doi:10.1074/jbc.M302546200.
- Kilmartin JV (2003). "Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication.". J. Cell Biol. 162 (7): 1211–21. PMC 2173958 . PMID 14504268. doi:10.1083/jcb.200307064.
- Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.". Mol. Biol. Cell. 15 (4): 1793–801. PMC 379276 . PMID 14767062. doi:10.1091/mbc.E03-09-0691.
- Tourbez M, Firanescu C, Yang A, et al. (2005). "Calcium-dependent self-assembly of human centrin 2.". J. Biol. Chem. 279 (46): 47672–80. PMID 15356003. doi:10.1074/jbc.M404996200.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
- Nishi R, Okuda Y, Watanabe E, et al. (2005). "Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein.". Mol. Cell. Biol. 25 (13): 5664–74. PMC 1156980 . PMID 15964821. doi:10.1128/MCB.25.13.5664-5674.2005.
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