Carboxylesterase 2
| CES2 | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||
| Aliases | CES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2 | ||||||||||||||||
| External IDs | MGI: 3648740 HomoloGene: 128645 GeneCards: CES2 | ||||||||||||||||
| |||||||||||||||||
| RNA expression pattern | |||||||||||||||||
   | |||||||||||||||||
| More reference expression data | |||||||||||||||||
| Orthologs | |||||||||||||||||
| Species | Human | Mouse | |||||||||||||||
| Entrez | |||||||||||||||||
| Ensembl | |||||||||||||||||
| UniProt | |||||||||||||||||
| RefSeq (mRNA) | |||||||||||||||||
| RefSeq (protein) | |||||||||||||||||
| Location (UCSC) | Chr 16: 66.93 – 66.95 Mb | Chr 8: 105 – 105.02 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
| Wikidata | |||||||||||||||||
| |||||||||||||||||
Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.[3][4][5] It is a member of the alpha/beta fold hydrolase family.[6]
Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[5]
Interactive pathway map
| Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]] Fluorouracil (5-FU) Activity edit
|
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
|{{{bSize}}}px|alt=Irinotecan Pathway edit]] Irinotecan Pathway edit
|
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (Jun 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J Biol Chem. 272 (23): 14769–75. PMID 9169443. doi:10.1074/jbc.272.23.14769.
- ↑ Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (Jun 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochem Biophys Res Commun. 233 (1): 117–20. PMID 9144407. doi:10.1006/bbrc.1997.6413.
- 1 2 "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
- ↑ Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. PMID 16858120. doi:10.2133/dmpk.21.173.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Yan B, Matoney L, Yang D (1999). "Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms.". Placenta. 20 (7): 599–607. PMID 10452915. doi:10.1053/plac.1999.0407.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948
. PMID 11076863. doi:10.1101/gr.143000. - Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
- Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. PMC 378590 . PMID 12417987. doi:10.1086/344580.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.". J. Hum. Genet. 48 (5): 249–70. PMID 12721789. doi:10.1007/s10038-003-0021-7.
- Wu MH, Chen P, Remo BF, et al. (2004). "Characterization of multiple promoters in the human carboxylesterase 2 gene.". Pharmacogenetics. 13 (7): 425–35. PMID 12835618. doi:10.1097/01.fpc.0000054103.48725.db.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Marsh S, Xiao M, Yu J, et al. (2005). "Pharmacogenomic assessment of carboxylesterases 1 and 2.". Genomics. 84 (4): 661–8. PMID 15475243. doi:10.1016/j.ygeno.2004.07.008.
- Wu MH, Chen P, Wu X, et al. (2005). "Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene.". Pharmacogenetics. 14 (9): 595–605. PMID 15475733. doi:10.1097/00008571-200409000-00004.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
- Charasson V, Bellott R, Meynard D, et al. (2005). "Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38.". Clin. Pharmacol. Ther. 76 (6): 528–35. PMID 15592324. doi:10.1016/j.clpt.2004.08.007.
- Kim SR, Nakamura T, Saito Y, et al. (2005). "Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2).". Drug Metab. Pharmacokinet. 18 (5): 327–32. PMID 15618752. doi:10.2133/dmpk.18.327.
- Fox CA, Sapinoso LM, Zhang H, et al. (2005). "Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas.". Neoplasia. 7 (4): 407–16. PMC 1501154 . PMID 15967118. doi:10.1593/neo.04715.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
This article is issued from
Wikipedia.
The text is licensed under Creative Commons - Attribution - Sharealike.
Additional terms may apply for the media files.