CENTA2

ADAP2

Identifiers

ADAP2, CENTA2, HSA272195, cent-b, ArfGAP with dual PH domains 2

External IDs

MGI: 2663075 HomoloGene: 10179 GeneCards: ADAP2

Gene ontology
Molecular function	• inositol 1,3,4,5 tetrakisphosphate binding • protein binding, bridging • phosphatidylinositol-4,5-bisphosphate binding • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding • GTPase activator activity • phosphatidylinositol-3,4-bisphosphate binding
Cellular component	• cytoplasm • plasma membrane • mitochondrial envelope • membrane
Biological process	• heart development • positive regulation of GTPase activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


55803


216991

Ensembl


ENSG00000184060


ENSMUSG00000020709

UniProt


Q9NPF8


Q8R2V5

RefSeq (mRNA)


NM_001346712 NM_001346714 NM_001346716 NM_018404


NM_172133

RefSeq (protein)


NP_001333641 NP_001333643 NP_001333645 NP_060874


NP_742145

Location (UCSC)

Chr 17: 30.91 – 30.96 Mb

Chr 11: 80.15 – 80.18 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Arf-GAP with dual PH domain-containing protein 2 is a protein that in humans is encoded by the ADAP2 gene.^[3]

References

External links

Human ADAP2 genome location and ADAP2 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Jenne DE, Tinschert S, Stegmann E, et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics. 66 (1): 93–7. PMID 10843809. doi:10.1006/geno.2000.6179.
Whitley P, Gibbard AM, Koumanov F, et al. (2003). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle". Eur. J. Cell Biol. 81 (4): 222–30. PMID 12018390. doi:10.1078/0171-9335-00242.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hanck T, Stricker R, Sedehizade F, Reiser G (2004). "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins". J. Neurochem. 88 (2): 326–36. PMID 14690521. doi:10.1046/j.1471-4159.2003.02143.x.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Venturin M, Bentivegna A, Moroni R, et al. (2005). "Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval". Ann. Hum. Genet. 69 (Pt 5): 508–16. PMID 16138909. doi:10.1111/j.1529-8817.2005.00203.x.
Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. PMID 17632510. doi:10.1038/ng2083.

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CENTA2

References

External links

Further reading