CDS1 (gene)

CDS1
Identifiers
AliasesCDS1, CDS, CDP-diacylglycerol synthase 1
External IDsMGI: 1921846 HomoloGene: 68173 GeneCards: CDS1
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1040

74596

Ensembl

ENSG00000163624

ENSMUSG00000029330

UniProt

Q92903

P98191

RefSeq (mRNA)

NM_001263

NM_173370

RefSeq (protein)

NP_001254

NP_775546

Location (UCSC)Chr 4: 84.58 – 84.65 MbChr 5: 101.77 – 101.82 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.[3][4][5]

Function

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.[6][7] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (Jan 1999). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. PMID 9806839. doi:10.1006/geno.1998.5547.
  4. Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (Apr 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA Cell Biol. 16 (3): 281–9. PMID 9115637. doi:10.1089/dna.1997.16.281.
  5. 1 2 "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".
  6. M. Nowicki & M. Frentzen (2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–2165. PMID 15811335. doi:10.1016/j.febslet.2005.03.007.
  7. M. Nowicki (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. thesis, RWTH-Aachen University.

Further reading


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