CDCA8
| CDCA8 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | CDCA8, BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8 | ||||||||||||||||
| External IDs | MGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 1: 37.69 – 37.71 Mb | Chr 4: 124.92 – 124.94 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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Borealin is a protein that in humans is encoded by the CDCA8 gene.[3][4][5]
Function
CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[5][6]
Interactions
CDCA8 has been shown to interact with INCENP,[6] Survivin[4][6] and Aurora B kinase.[4][6]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. PMID 12188893. doi:10.2174/1568009013334241.
- 1 2 3 Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. PMID 15260989. doi:10.1016/j.cell.2004.06.026.
- 1 2 "Entrez Gene: CDCA8 cell division cycle associated 8".
- 1 2 3 4 Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. PMC 2172304
. PMID 15249581. doi:10.1083/jcb.200404001.
Further reading
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH (Jan 2005). "Proteome analysis of the human mitotic spindle". Molecular & Cellular Proteomics. 4 (1): 35–43. PMID 15561729. doi:10.1074/mcp.M400158-MCP200.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. PMID 15635413. doi:10.1038/nature03207.
- Vader G, Kauw JJ, Medema RH, Lens SM (Jan 2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Reports. 7 (1): 85–92. PMC 1369225 . PMID 16239925. doi:10.1038/sj.embor.7400562.
- Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP (Jan 2006). "Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis". The Journal of Biological Chemistry. 281 (2): 1286–95. PMID 16291752. doi:10.1074/jbc.M508773200.
- Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM (Apr 2006). "Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer". Experimental Cell Research. 312 (7): 962–73. PMID 16427043. doi:10.1016/j.yexcr.2005.12.015.
- Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH (Apr 2006). "Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres". Molecular Biology of the Cell. 17 (4): 1897–909. PMC 1415303 . PMID 16436504. doi:10.1091/mbc.E05-08-0727.
- Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G (Aug 2006). "Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown". Oncogene. 25 (35): 4867–79. PMID 16547492. doi:10.1038/sj.onc.1209499.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. PMC 1459365 . PMID 16565220. doi:10.1073/pnas.0507066103.
- Klein UR, Nigg EA, Gruneberg U (Jun 2006). "Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP". Molecular Biology of the Cell. 17 (6): 2547–58. PMC 1474794 . PMID 16571674. doi:10.1091/mbc.E05-12-1133.
- Kaur H, Stiff AC, Date DA, Taylor WR (2007). "Analysis of mitotic phosphorylation of borealin". BMC Cell Biology. 8: 5. PMC 1794407 . PMID 17241471. doi:10.1186/1471-2121-8-5.
- Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y (May 2007). "Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis". Cancer Research. 67 (9): 4113–22. PMID 17483322. doi:10.1158/0008-5472.CAN-06-4705.
External links
- Human CDCA8 genome location and CDCA8 gene details page in the UCSC Genome Browser.
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