CDC6

CDC6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC6, CDC18L, HsCDC18, Hscell division cycle 6, MGORS5
External IDsMGI: 1345150 HomoloGene: 68172 GeneCards: CDC6
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

990

23834

Ensembl

ENSG00000094804

ENSMUSG00000017499

UniProt

Q99741

O89033

RefSeq (mRNA)

NM_001254

NM_001025779
NM_011799

RefSeq (protein)

NP_001245

NP_001020950
NP_035929

Location (UCSC)Chr 17: 40.29 – 40.3 MbChr 11: 98.91 – 98.92 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.[3][4]

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.[5]

Interactions

CDC6 has been shown to interact with ORC1L,[4][6] ORC2L,[6][7] Cyclin A2,[4][8] PPP2R3B,[9] MCM3,[7][10] PPP2R3A,[11] MCM7[6][10] and PSKH1.[8]

See also

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Williams RS, Shohet RV, Stillman B (February 1997). "A human protein related to yeast Cdc6p". Proc Natl Acad Sci U S A. 94 (1): 142–7. PMC 19260 Freely accessible. PMID 8990175. doi:10.1073/pnas.94.1.142.
  4. 1 2 3 Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A (May 1998). "Human CDC6/Cdc18 Associates with Orc1 and Cyclin-cdk and Is Selectively Eliminated from the Nucleus at the Onset of S Phase". Mol Cell Biol. 18 (5): 2758–67. PMC 110655 Freely accessible. PMID 9566895. doi:10.1128/mcb.18.5.2758.
  5. ↑ "Entrez Gene: CDC6 cell division cycle 6 homolog (S. cerevisiae)".
  6. 1 2 3 Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. England. 327 (1): 111–28. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2.
  7. 1 2 Méndez, J; Stillman B (November 2000). "Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis". Mol. Cell. Biol. UNITED STATES. 20 (22): 8602–12. ISSN 0270-7306. PMC 102165 Freely accessible. PMID 11046155. doi:10.1128/MCB.20.22.8602-8612.2000.
  8. 1 2 Petersen, B O; Lukas J; Sørensen C S; Bartek J; Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. ENGLAND. 18 (2): 396–410. ISSN 0261-4189. PMC 1171134 Freely accessible. PMID 9889196. doi:10.1093/emboj/18.2.396.
  9. ↑ Yan, Z; Fedorov S A; Mumby M C; Williams R S (February 2000). "PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells". Mol. Cell. Biol. UNITED STATES. 20 (3): 1021–9. ISSN 0270-7306. PMC 85219 Freely accessible. PMID 10629059. doi:10.1128/MCB.20.3.1021-1029.2000.
  10. 1 2 Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. UNITED STATES. 274 (36): 25927–32. ISSN 0021-9258. PMID 10464337. doi:10.1074/jbc.274.36.25927.
  11. ↑ Davis, Anthony J; Yan Zhen; Martinez Bobbie; Mumby Marc C (June 2008). "Protein Phosphatase 2A Is Targeted to Cell Division Control Protein 6 by a Calcium-binding Regulatory Subunit". J. Biol. Chem. United States. 283 (23): 16104–14. ISSN 0021-9258. PMC 2414307 Freely accessible. PMID 18397887. doi:10.1074/jbc.M710313200.

Further reading

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