CD3EAP

CD3EAP
Identifiers
AliasesCD3EAP, ASE-1, ASE1, CAST, PAF49, CD3e molecule associated protein
External IDsMGI: 1917583 HomoloGene: 17107 GeneCards: CD3EAP
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10849

70333

Ensembl

ENSG00000117877

ENSMUSG00000047649

UniProt

O15446

Q76KJ5

RefSeq (mRNA)

NM_012099
NM_001297590

NM_145822

RefSeq (protein)

NP_001284519
NP_036231

NP_665821

Location (UCSC)Chr 19: 45.41 – 45.41 MbChr 7: 19.36 – 19.36 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene.[3][4][5][6]

Interactions

CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain,[3] POLR1E[5] and POLR1C.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. 1 2 Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (Jul 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J Biol Chem. 274 (26): 18173–80. PMID 10373416. doi:10.1074/jbc.274.26.18173.
  4. Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (Mar 1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes". Chromosoma. 106 (8): 493–502. PMID 9426281. doi:10.1007/s004120050271.
  5. 1 2 3 Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jun 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol Cell Biol. 24 (14): 6338–49. PMC 434256Freely accessible. PMID 15226435. doi:10.1128/MCB.24.14.6338-6349.2004.
  6. "Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein".

Further reading


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