CD200R1
| CD200R1 | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | CD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1 | ||||||||||||||||
| External IDs | MGI: 1889024 HomoloGene: 10957 GeneCards: CD200R1 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 3: 112.92 – 112.98 Mb | Chr 16: 44.77 – 44.79 Mb | |||||||||||||||
| PubMed search | [1] | [2] | |||||||||||||||
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Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.[3][4][5]
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Wright GJ, Puklavec MJ, Willis AC, Hoek RM, Sedgwick JD, Brown MH, Barclay AN (Sep 2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function". Immunity. 13 (2): 233–42. PMID 10981966. doi:10.1016/S1074-7613(00)00023-6.
- ↑ Dick AD, Broderick C, Forrester JV, Wright GJ (Jan 2001). "Distribution of OX2 antigen and OX2 receptor within retina". Invest Ophthalmol Vis Sci. 42 (1): 170–6. PMID 11133863.
- 1 2 "Entrez Gene: CD200R1 CD200 receptor 1".
Further reading
- Matsue H (2006). "CD 200-mediated regulation of skin immunity.". J. Invest. Dermatol. 125 (6): x–xi. PMID 16354172. doi:10.1111/j.0022-202X.2005.23978.x.
- Shiratori I, Yamaguchi M, Suzukawa M, et al. (2005). "Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200.". J. Immunol. 175 (7): 4441–9. PMID 16177086. doi:10.4049/jimmunol.175.7.4441.
- Cherwinski HM, Murphy CA, Joyce BL, et al. (2005). "The CD200 receptor is a novel and potent regulator of murine and human mast cell function.". J. Immunol. 174 (3): 1348–56. PMID 15661892. doi:10.4049/jimmunol.174.3.1348.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. PMC 2286551
. PMID 15340161. doi:10.1110/ps.04682504. - Foster-Cuevas M, Wright GJ, Puklavec MJ, et al. (2004). "Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.". J. Virol. 78 (14): 7667–76. PMC 434103 . PMID 15220441. doi:10.1128/JVI.78.14.7667-7676.2004.
- Karteris E, Chen J, Randeva HS (2004). "Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.". J. Clin. Endocrinol. Metab. 89 (4): 1957–62. PMID 15070969. doi:10.1210/jc.2003-031778.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. PMC 403697 . PMID 12975309. doi:10.1101/gr.1293003.
- Wright GJ, Cherwinski H, Foster-Cuevas M, et al. (2003). "Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.". J. Immunol. 171 (6): 3034–46. PMID 12960329. doi:10.4049/jimmunol.171.6.3034.
- Vieites JM, de la Torre R, Ortega MA, et al. (2003). "Characterization of human cd200 glycoprotein receptor gene located on chromosome 3q12-13.". Gene. 311: 99–104. PMID 12853143. doi:10.1016/S0378-1119(03)00562-6.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
External links
- CD200R1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD200R1 genome location and CD200R1 gene details page in the UCSC Genome Browser.
- Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser.
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