CD180
| CD180 | |||||||||||||||
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| Identifiers | |||||||||||||||
| Aliases | CD180, LY64, Ly78, RP105, CD180 molecule | ||||||||||||||
| External IDs | MGI: 1194924 HomoloGene: 4077 GeneCards: CD180 | ||||||||||||||
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| Species | Human | Mouse | |||||||||||||
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| RefSeq (protein) | |||||||||||||||
| Location (UCSC) | Chr 5: 67.18 – 67.2 Mb | Chr 13: 102.69 – 102.74 Mb | |||||||||||||
| PubMed search | [1] | [2] | |||||||||||||
| Wikidata | |||||||||||||||
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CD180 antigen is a protein that in humans is encoded by the CD180 gene.[3][4][5][6]
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–22. PMID 9763566.
- ↑ Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. PMID 8975706. doi:10.1006/geno.1996.0632.
- 1 2 "Entrez Gene: CD180 CD180 molecule".
- ↑ [4]
External links
- Human CD180 genome location and CD180 gene details page in the UCSC Genome Browser.
Further reading
- Honda Y, Yamagiwa S, Matsuda Y, et al. (2007). "Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis.". J. Hepatol. 47 (3): 404–11. PMID 17448566. doi:10.1016/j.jhep.2007.03.012.
- Divanovic S, Trompette A, Atabani SF, et al. (2005). "Negative Regulation of TLR4 Signaling by RP105". Nat. Immunol. 6 (6): 571–8. PMC 2144914
. PMID 15852007. doi:10.1038/ni1198. - Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. PMC 2286551 . PMID 15340161. doi:10.1110/ps.04682504.
- Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. PMID 12539042. doi:10.1038/nm822.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Miyake K, Shimazu R, Kondo J, et al. (1998). "Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression". J. Immunol. 161 (3): 1348–53. PMID 9686597.
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