SLAMF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1M27, 1KA7, 1I3Z, 1D4T, 1D4W, 1KA6

Identifiers

Aliases

SLAMF1, CD150, CDw150, SLAM, signaling lymphocytic activation molecule family member 1

External IDs

MGI: 1351314 HomoloGene: 48162 GeneCards: SLAMF1

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	160,608,100 bp^[1]
Band	No data available	End	160,647,295 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	No data available	Start	171,767,127 bp^[2]
Band	No data available	End	171,801,184 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• receptor activity • antigen binding • virus receptor activity • protein binding • transmembrane signaling receptor activity • identical protein binding
Cellular component	• integral component of membrane • membrane • plasma membrane • extracellular region • cell surface • phagocytic vesicle • extracellular exosome • external side of plasma membrane
Biological process	• adaptive immune response • immune system process • natural killer cell proliferation • T-helper 1 cell cytokine production • negative regulation of interferon-gamma secretion • negative regulation of interleukin-6 production • positive regulation of JNK cascade • cell adhesion • negative regulation of CD40 signaling pathway • negative regulation of T cell cytokine production • positive regulation of interferon-gamma secretion • myeloid dendritic cell activation involved in immune response • regulation of vesicle fusion • positive regulation of cell proliferation • positive regulation of ERK1 and ERK2 cascade • phagocytosis • lymphocyte activation • viral entry into host cell • negative regulation of tumor necrosis factor production • innate immune response • regulation of catalytic activity • viral process • positive regulation of activated T cell proliferation • negative regulation of interleukin-12 production • natural killer cell differentiation • signal transduction • leukocyte chemotaxis involved in inflammatory response • positive regulation of macrophage chemotaxis • positive regulation of dendritic cell chemotaxis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6504


27218

Ensembl


ENSG00000117090


ENSMUSG00000015316

UniProt


Q13291


Q9QUM4

RefSeq (mRNA)


NM_003037 NM_001330754


NM_013730

RefSeq (protein)


NP_001317683 NP_003028


NP_038758

Location (UCSC)

Chr 1: 160.61 – 160.65 Mb

Chr 1: 171.77 – 171.8 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene.^[5]^[6] Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150).

SLAMF1 belongs to the signaling lymphocytic activation molecule family. The interaction of SLAMF1 promoter and enhancers with the Early B-cell factor 1 (EBF1) is required for the expression of SLAMF1 gene in B cells. STAT6, IRF4, and NF-kB factors involved in the transfer of the signals from the B-cell receptor, its co-receptors and IL-4R, also play important role in the regulation of SLAMF1 expression.^[7]

Interactions

SLAMF1 has been shown to interact with PTPN11,^[8]^[9] SH2D1A^[8]^[10] and SH2D1B.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117090 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015316 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (August 1995). "A novel receptor involved in T-cell activation". Nature. 376 (6537): 260–3. PMID 7617038. doi:10.1038/376260a0.
↑ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1".
↑ Schwartz, Anton M.; Putlyaeva, Lidia V.; Covich, Milica; Klepikova, Anna V.; Akulich, Kseniya A.; Vorontsov, Ilya E.; Korneev, Kirill V.; Dmitriev, Sergey E.; Polanovsky, Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004.
1 2 Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (February 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood. 99 (3): 957–65. PMID 11806999. doi:10.1182/blood.V99.3.957.
1 2 Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (November 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. PMC 125701 . PMID 11689425. doi:10.1093/emboj/20.21.5840.
↑ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (September 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. PMID 11477068. doi:10.1074/jbc.M101305200.

Punnonen J, Cocks BG, Carballido JM, Bennett B, Peterson D, Aversa G, de Vries JE (1997). "Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes.". J. Exp. Med. 185 (6): 993–1004. PMC 2196230 . PMID 9091591. doi:10.1084/jem.185.6.993.
Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C (1998). "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.". Nature. 395 (6701): 462–9. PMID 9774102. doi:10.1038/26683.
Mikhalap SV, Shlapatska LM, Berdova AG, Law CL, Clark EA, Sidorenko SP (1999). "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.". J. Immunol. 162 (10): 5719–27. PMID 10229804.
Li SC, Gish G, Yang D, Coffey AJ, Forman-Kay JD, Ernberg I, Kay LE, Pawson T (2000). "Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.". Curr. Biol. 9 (23): 1355–62. PMID 10607564. doi:10.1016/S0960-9822(00)80080-9.
Rogge L, Bianchi E, Biffi M, Bono E, Chang SY, Alexander H, Santini C, Ferrari G, Sinigaglia L, Seiler M, Neeb M, Mous J, Sinigaglia F, Certa U (2000). "Transcript imaging of the development of human T helper cells using oligonucleotide arrays.". Nat. Genet. 25 (1): 96–101. PMID 10802665. doi:10.1038/75671.
Tatsuo H, Ono N, Tanaka K, Yanagi Y (2000). "SLAM (CDw150) is a cellular receptor for measles virus.". Nature. 406 (6798): 893–7. PMID 10972291. doi:10.1038/35022579.
Lewis J, Eiben LJ, Nelson DL, Cohen JI, Nichols KE, Ochs HD, Notarangelo LD, Duckett CS (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.". Clin. Immunol. 100 (1): 15–23. PMID 11414741. doi:10.1006/clim.2001.5035.
Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809–16. PMID 11477068. doi:10.1074/jbc.M101305200.
Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, Schuler G, Steinkasserer A (2001). "Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta.". J. Immunol. 167 (4): 1989–95. PMID 11489980. doi:10.4049/jimmunol.167.4.1989.
Bleharski JR, Niazi KR, Sieling PA, Cheng G, Modlin RL (2001). "Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines.". J. Immunol. 167 (6): 3174–81. PMID 11544303. doi:10.4049/jimmunol.167.6.3174.
Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. PMC 125701 . PMID 11689425. doi:10.1093/emboj/20.21.5840.
Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C (2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.". Blood. 99 (3): 957–65. PMID 11806999. doi:10.1182/blood.V99.3.957.
Murabayashi N, Kurita-Taniguchi M, Ayata M, Matsumoto M, Ogura H, Seya T (2002). "Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification.". Microbes Infect. 4 (8): 785–94. PMID 12270725. doi:10.1016/S1286-4579(02)01598-8.
Li C, Iosef C, Jia CY, Han VK, Li SS (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.". J. Biol. Chem. 278 (6): 3852–9. PMID 12458214. doi:10.1074/jbc.M206649200.
Hahm B, Arbour N, Naniche D, Homann D, Manchester M, Oldstone MB (2003). "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule.". J. Virol. 77 (6): 3505–15. PMC 149525 . PMID 12610126. doi:10.1128/JVI.77.6.3505-3515.2003.
Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430–7. PMID 12621057. doi:10.1074/jbc.M301569200.
Ferrand V, Li C, Romeo G, Yin L (2003). "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients.". J. Med. Virol. 70 (1): 131–6. PMID 12629654. doi:10.1002/jmv.10373.
Laaksonen K, Junikka M, Lahesmaa R, Terho EO, Savolainen J (2004). "In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy.". J. Allergy Clin. Immunol. 112 (6): 1171–7. PMID 14657878. doi:10.1016/j.jaci.2003.08.043.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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SLAMF1

Interactions

References

Further reading