CCNL2

CCNL2

Identifiers

CCNL2, ANIA-6B, CCNM, CCNS, HCLA-ISO, HLA-ISO, PCEE, SB138, cyclin L2

External IDs

MGI: 1927119 HomoloGene: 69477 GeneCards: CCNL2

Gene ontology
Molecular function	• cyclin-dependent protein serine/threonine kinase regulator activity • protein kinase binding • protein binding
Cellular component	• nucleus • cyclin-dependent protein kinase holoenzyme complex • intracellular membrane-bounded organelle • nuclear speck • nucleoplasm
Biological process	• regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of phosphorylation of RNA polymerase II C-terminal domain • regulation of cyclin-dependent protein serine/threonine kinase activity • positive regulation of cyclin-dependent protein serine/threonine kinase activity • transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


81669


56036


ENSG00000221978


ENSMUSG00000029068


Q96S94


Q9JJA7

RefSeq (mRNA)

NM_001039577 NM_001144867 NM_001144868 NM_030937 NM_001320153
NM_001320155 NM_001350497 NM_001350498 NM_001350499 NM_001350500


NM_018856 NM_207678

RefSeq (protein)

NP_001034666 NP_001307082 NP_001307084 NP_112199 NP_001337426
NP_001337427 NP_001337428 NP_001337429


NP_997561

Location (UCSC)

Chr 1: 1.39 – 1.4 Mb

Chr 4: 155.81 – 155.82 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene.^[3] The protein encoded by this gene belongs to cyclin family.

CCNL2 gene also called

Cyclin L2	HLA-ISO
Paneth Cell-Enhanced Expression Protein	SB138
Cyclin S	CCNS
Cyclin M	PCEE
Cyclin-L2	CCNM
HCLA-ISO
ANIA-6B

Table Source: genecards.org

References

External links

Human CCNL2 genome location and CCNL2 gene details page in the UCSC Genome Browser.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Cheng H, Bjerknes M (1996). "Patterns of gene expression along the crypt-villus axis in mouse jejunal epithelium". Anat. Rec. 244 (1): 78–94. PMID 8838426. doi:10.1002/(SICI)1097-0185(199601)244:1<78::AID-AR8>3.0.CO;2-B.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. PMID 14623875. doi:10.1074/jbc.M310794200.
Yang L, Li N, Wang C, et al. (2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells". J. Biol. Chem. 279 (12): 11639–48. PMID 14684736. doi:10.1074/jbc.M312895200.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.

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