CAMK4
Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.[3]
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.[4]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE (Mar 1989). "Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV". Genomics. 4 (1): 21–7. PMID 2536634. doi:10.1016/0888-7543(89)90309-1.
- ↑ "Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV".
Further reading
- Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. PMID 1375933.
- Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N (1991). "Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2850–3. PMC 51337
. PMID 2011593. doi:10.1073/pnas.88.7.2850. - Selbert MA, Anderson KA, Huang QH, et al. (1995). "Phosphorylation and activation of Ca2+-calmodulin-dependent protein kinase IV by Ca2+-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation". J. Biol. Chem. 270 (29): 17616–21. PMID 7615569. doi:10.1074/jbc.270.29.17616.
- Kitani T, Okuno S, Fujisawa H (1994). "cDNA cloning and expression of human calmodulin-dependent protein kinase IV". J. Biochem. 115 (4): 637–40. PMID 8089075.
- Mosialos G, Hanissian SH, Jawahar S, et al. (1994). "A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1". J. Virol. 68 (3): 1697–705. PMC 236629 . PMID 8107230.
- Bland MM, Monroe RS, Ohmstede CA (1994). "The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus". Gene. 142 (2): 191–7. PMID 8194751. doi:10.1016/0378-1119(94)90260-7.
- Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade". J. Biol. Chem. 271 (10): 5617–22. PMID 8621423. doi:10.1074/jbc.271.10.5617.
- Chatila T, Anderson KA, Ho N, Means AR (1996). "A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR". J. Biol. Chem. 271 (35): 21542–8. PMID 8702940. doi:10.1074/jbc.271.35.21542.
- Melander Gradin H, Marklund U, Larsson N, et al. (1997). "Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18". Mol. Cell. Biol. 17 (6): 3459–67. PMC 232199 . PMID 9154845.
- Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. PMID 9705275. doi:10.1074/jbc.273.34.21473.
- Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. PMID 9822657. doi:10.1074/jbc.273.48.31880.
- Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. PMID 10400690. doi:10.1074/jbc.274.29.20597.
- Blaeser F, Ho N, Prywes R, Chatila TA (2000). "Ca2+-dependent gene expression mediated by MEF2 transcription factors". J. Biol. Chem. 275 (1): 197–209. PMID 10617605. doi:10.1074/jbc.275.1.197.
- Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. PMC 3505218 . PMID 10681496. doi:10.1074/jbc.275.8.5257.
- Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. PMID 10874031. doi:10.1074/jbc.M003198200.
- Wu JY, Ribar TJ, Cummings DE, et al. (2000). "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4". Nat. Genet. 25 (4): 448–52. PMID 10932193. doi:10.1038/78153.
- Jang MK, Goo YH, Sohn YC, et al. (2001). "Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit". J. Biol. Chem. 276 (23): 20005–10. PMID 11274168. doi:10.1074/jbc.M010211200.
- Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. PMID 11395482. doi:10.1074/jbc.M011720200.
- Zhao X, Ito A, Kane CD, et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking". J. Biol. Chem. 276 (37): 35042–8. PMID 11470791. doi:10.1074/jbc.M105086200.
- Ainhoa Bilbaoa; Jan Rodriguez Parkitnab; David Engblomb; Stéphanie Perreau-Lenza; Carles Sanchis-Seguraa; Miriam Schneidera; Witold Konopkab; Magdalena Westphalb; Gerome Breenc; Sylvane Desrivieresc; Matthias Klugmannd; Camila Guindalinie; Homero Valladag; Ronaldo Laranjeirae; Fernando Rodriguez de Fonsecah; Gunter Schumannc; Günther Schützb & Rainer Spanagela (2008). "Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine". Proceedings of the National Academy of Sciences of the United States of America. PNAS. 105 (45): 17549–54. PMC 2582267 . PMID 19001277. doi:10.1073/pnas.0803959105.
- Feliciano DM & Edelman AM (2009). "Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells.". J. Biol. Chem. 284 (39): 26466–81. PMC 2785335 . PMID 19633294. doi:10.1074/jbc.M109.027680.
External links
- Human CAMK4 genome location and CAMK4 gene details page in the UCSC Genome Browser.
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