Calumenin

CALU

Identifiers

CALU, calumenin

External IDs

MGI: 1097158 HomoloGene: 936 GeneCards: CALU

Gene ontology
Molecular function	• calcium ion binding • metal ion binding • protein binding
Cellular component	• Golgi apparatus • endoplasmic reticulum membrane • membrane • melanosome • sarcoplasmic reticulum • extracellular region • endoplasmic reticulum • sarcoplasmic reticulum lumen • endoplasmic reticulum lumen
Biological process	• post-translational protein modification • cellular protein metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


813


12321


ENSG00000128595


ENSMUSG00000029767


O43852


O35887

RefSeq (mRNA)

NM_001130674 NM_001199671 NM_001199672 NM_001199673 NM_001199674
NM_001219


NM_001285412 NM_007594 NM_184053

RefSeq (protein)


NP_001124146 NP_001186600 NP_001186601 NP_001186602 NP_001210


NP_001272341 NP_031620 NP_908942

Location (UCSC)

Chr 7: 128.74 – 128.77 Mb

Chr 6: 29.35 – 29.38 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Calumenin is a protein that in humans is encoded by the CALU gene.^[3]^[4]

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Yabe D, Taniwaki M, Nakamura T, Kanazawa N, Tashiro K, Honjo T (Aug 1998). "Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32". Genomics. 49 (2): 331–3. PMID 9598325. doi:10.1006/geno.1998.5245.
1 2 "Entrez Gene: CALU calumenin".

External links

Human CALU genome location and CALU gene details page in the UCSC Genome Browser.

Further reading

Yabe D, Nakamura T, Kanazawa N, et al. (1997). "Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF". J. Biol. Chem. 272 (29): 18232–9. PMID 9218460. doi:10.1074/jbc.272.29.18232.
Vorum H, Liu X, Madsen P, et al. (1998). "Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity". Biochim. Biophys. Acta. 1386 (1): 121–31. PMID 9675259. doi:10.1016/s0167-4838(98)00089-2.
Hseu MJ, Yen CH, Tzeng MC (1999). "Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin, a neurotoxic phospholipase A2". FEBS Lett. 445 (2–3): 440–4. PMID 10094503. doi:10.1016/S0014-5793(99)00177-5.
Vorum H, Hager H, Christensen BM, et al. (1999). "Human calumenin localizes to the secretory pathway and is secreted to the medium". Exp. Cell Res. 248 (2): 473–81. PMID 10222138. doi:10.1006/excr.1999.4431.
Vorum H, Jacobsen C, Honoré B (2000). "Calumenin interacts with serum amyloid P component". FEBS Lett. 465 (2–3): 129–34. PMID 10631319. doi:10.1016/S0014-5793(99)01734-2.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. PMID 12643545. doi:10.1021/pr025562r.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. PMID 12665801. doi:10.1038/nbt810.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. PMID 17081065. doi:10.1021/pr060363j.

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