CALML5

CALML5

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2B1U

Identifiers

CALML5, CLSP, calmodulin like 5

External IDs

MGI: 1931464 HomoloGene: 49485 GeneCards: CALML5

Gene ontology
Molecular function	• metal ion binding • calcium ion binding
Cellular component	• extracellular exosome • extracellular region • ficolin-1-rich granule lumen
Biological process	• signal transduction • epidermis development • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


51806


80796


ENSG00000178372


ENSMUSG00000033765


Q9NZT1


Q9JM83

RefSeq (mRNA)


NM_017422


NM_020036

RefSeq (protein)


NP_059118


NP_064420

Location (UCSC)

Chr 10: 5.5 – 5.5 Mb

Chr 13: 3.84 – 3.84 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.^[3]^[4]

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R (Jun 2000). "Identification and cloning of a new calmodulin-like protein from human epidermis". J Biol Chem. 275 (17): 12841–7. PMID 10777582. doi:10.1074/jbc.275.17.12841.
1 2 "Entrez Gene: CALML5 calmodulin-like 5".

External links

Human CALML5 genome location and CALML5 gene details page in the UCSC Genome Browser.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Méhul B, Bernard D, Schmidt R (2001). "Calmodulin-like skin protein: a new marker of keratinocyte differentiation". J. Invest. Dermatol. 116 (6): 905–9. PMID 11407979. doi:10.1046/j.0022-202x.2001.01376.x.
Durussel I, Méhul B, Bernard D, et al. (2002). "Cation- and peptide-binding properties of human calmodulin-like skin protein". Biochemistry. 41 (17): 5439–48. PMID 11969404. doi:10.1021/bi016062z.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Méhul B, Bernard D, Brouard M, et al. (2006). "Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis". Exp. Dermatol. 15 (6): 469–77. PMID 16689864. doi:10.1111/j.1600-0625.2006.00433.x.
Babini E, Bertini I, Capozzi F, et al. (2006). "A structural and dynamic characterization of the EF-hand protein CLSP". Structure. 14 (6): 1029–38. PMID 16765896. doi:10.1016/j.str.2006.04.004.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

PDB gallery

2b1u: Solution structure of Calmodulin-like Skin Protein C terminal domain

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