CFLAR

CFLAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H11, 3H13, 2N5R
Identifiers
Aliases	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator
External IDs	MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
Gene ontology Molecular function • death receptor binding • cysteine-type peptidase activity • protein complex binding • protease binding • protein binding • cysteine-type endopeptidase activity involved in execution phase of apoptosis • enzyme activator activity • cysteine-type endopeptidase activity Cellular component • cytoplasm • cytosol • CD95 death-inducing signaling complex • ripoptosome • death-inducing signaling complex • membrane raft Biological process • regulation of apoptotic process • execution phase of apoptosis • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic process • proteolysis • skeletal myofibril assembly • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • negative regulation of myoblast fusion • skeletal muscle atrophy • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of necroptotic process • regulation of extrinsic apoptotic signaling pathway via death domain receptors • viral process • regulation of skeletal muscle satellite cell proliferation • skeletal muscle tissue development • apoptotic process • positive regulation of catalytic activity • response to hypoxia • negative regulation of cardiac muscle cell apoptotic process • positive regulation of neuron projection development • cellular response to insulin stimulus • response to testosterone • positive regulation of ERK1 and ERK2 cascade • cellular response to epidermal growth factor stimulus • cellular response to estradiol stimulus • cellular response to hypoxia • cellular response to dexamethasone stimulus • cellular response to nitric oxide • positive regulation of glomerular mesangial cell proliferation • positive regulation of extracellular matrix organization • negative regulation of reactive oxygen species biosynthetic process • negative regulation of cellular response to transforming growth factor beta stimulus • negative regulation of hepatocyte apoptotic process • negative regulation of epithelial cell apoptotic process • positive regulation of hepatocyte proliferation • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8837	12633
Ensembl	n/a	ENSMUSG00000026031
UniProt	O15519	O35732
RefSeq (mRNA)	NM_001127183 NM_001127184 NM_001202515 NM_001202516 NM_001202517 NM_001202518 NM_001202519 NM_001308042 NM_001308043 NM_003879	NM_001289704 NM_001293804 NM_001293805 NM_009805 NM_207653
RefSeq (protein)	NP_001120655 NP_001120656 NP_001189444 NP_001189445 NP_001189446 NP_001189447 NP_001189448 NP_001294971 NP_001294972 NP_003870 NP_001338519 NP_001338520 NP_001338521 NP_001338522 NP_001338523	NP_001276633 NP_001280733 NP_001280734 NP_033935 NP_997536
Location (UCSC)	n/a	Chr 1: 58.71 – 58.76 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[3][4] Also called c-FLIP (FLICE-like inhibitory protein).

References

External links

• Human CFLAR genome location and CFLAR gene details page in the UCSC Genome Browser.

Further reading