Butyrophilin, subfamily 2, member A2
Butyrophilin subfamily 2 member A2 is a protein that in humans is encoded by the BTN2A2 gene.[3][4][5]
Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type 1 receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Henry J, Miller MM, Pontarotti P (Jul 1999). "Structure and evolution of the extended B7 family". Immunol Today. 20 (6): 285–8. PMID 10354554. doi:10.1016/S0167-5699(98)01418-2.
- ↑ Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R Jr, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (Aug 1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. PMID 9149941. doi:10.1101/gr.7.5.441.
- 1 2 "Entrez Gene: BTN2A2 butyrophilin, subfamily 2, member A2".
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Cavaletto M, Giuffrida MG, Fortunato D, et al. (2003). "A proteomic approach to evaluate the butyrophilin gene family expression in human milk fat globule membrane.". Proteomics. 2 (7): 850–6. PMID 12124930. doi:10.1002/1615-9861(200207)2:7<850::AID-PROT850>3.0.CO;2-C.
- Rhodes DA, Stammers M, Malcherek G, et al. (2001). "The cluster of BTN genes in the extended major histocompatibility complex.". Genomics. 71 (3): 351–62. PMID 11170752. doi:10.1006/geno.2000.6406.
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