Boston's sign

Boston's sign is the spasmodic lowering of the upper eyelid on downward rotation of the eye, indicating exophthalmic goiter.^[1]

Similar to von Graefe's sign, it is observed in people with Graves-Basedow disease, a type of hyperthyroidism. In this disease, the immune system attacks the thyroid gland and the soft tissues surrounding the eyes. As a result, the eyes are often pushed forward in the eye sockets, a condition known as exophthalmos.

References

↑ Cline D; Hofstetter HW; Griffin JR. Dictionary of Visual Science. 4th ed. Butterworth-Heinemann, Boston 1997. ISBN 0-7506-9895-0

Symptoms and medical signs relating to the eye
Adnexa	lacrimal: Schirmer's test eyelid: Abadie's sign of exophthalmic goiter Boston's sign Dalrymple's sign Stellwag's sign
Globe	pupil: Argyll Robertson pupils Adie pupil Marcus Gunn pupil iris: Fleischer ring Kayser-Fleischer ring Brushfield spots Lisch nodule conjunctiva: Bitot's spots Arlt's line retina: Hollenhorst plaque Roth's spot Fuchs spot others: Alexander's law Hirschberg test Siegrist streaks Hudson–Stahli line

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