Binding domain

A binding domain is a protein domain which binds to a specific atom or molecule, such as calcium or DNA. Protein Domain is a part of a protein sequence and a tertiary structure that can change, function, and live by itself for the rest of the protein chain. (Phillips 1). Upon binding, proteins may undergo a conformational change. Binding domains are essential for the function of many proteins. They are essential because they help splice, assemble, and translate proteins. (Yong 1).

Examples of binding domains include Zinc finger, which binds to DNA, and EF hand, which binds to calcium.

References

Phillips DC. (1966). "The three-dimensional structure of an enzyme molecule". Scientific American. 215 (5): 78–90. doi:10.1038/scientificamerican1166-78. PMID 5978599.
Yong, J., T. J. Golembe, D. J. Battle, L. Pellizzoni, and G. Dreyfuss. "SnRNAs Contain Specific SMN-binding Domains That Are Essential for SnRNP Assembly." Molecular and Cellular Biology. U.S. National Library of Medicine, Apr. 2004. Web. 06 Apr. 2017.

Proteins

Processes

Structures

Types

Proteins: key methods of study
Experimental	Protein purification Green fluorescent protein Western blot Protein immunostaining Protein sequencing Gel electrophoresis/Protein electrophoresis Protein immunoprecipitation Peptide mass fingerprinting/Protein mass spectrometry Dual-polarization interferometry Microscale thermophoresis Chromatin immunoprecipitation Surface plasmon resonance Isothermal titration calorimetry X-ray crystallography Protein NMR Cryo-electron microscopy Freeze-fracture electron microscopy
Bioinformatics	Protein structure prediction Protein–protein docking Protein structural alignment Protein ontology Protein–protein interaction prediction
Assay	Enzyme assay Protein assay Secretion assay
Display techniques	Bacterial display mRNA display Phage display Ribosome display Yeast display
Super-resolution microscopy	Photoactivated localization microscopy Vertico SMI

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Binding domain

See also

References