Beta-cubebene synthase

Beta-cubebene synthase
Identifiers
EC number 4.2.3.128
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Beta-cubebene synthase (EC 4.2.3.128, cop4, Mg25) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, beta-cubebene-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate beta-cubebene + diphosphate

Isolated from the fungus Coprinus cinereus.

References

  1. ↑ Lee, S.; Chappell, J. (2008). "Biochemical and genomic characterization of terpene synthases in Magnolia grandiflora". Plant Physiol. 147: 1017–1033. PMC 2442544 Freely accessible. PMID 18467455. doi:10.1104/pp.108.115824.
  2. ↑ Agger, S.; Lopez-Gallego, F.; Schmidt-Dannert, C. (2009). "Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus". Mol. Microbiol. 72: 1181–1195. PMC 2723806 Freely accessible. PMID 19400802. doi:10.1111/j.1365-2958.2009.06717.x.
  3. ↑ Lopez-Gallego, F.; Agger, S.A.; Abate-Pella, D.; Distefano, M.D.; Schmidt-Dannert, C. (2010). "Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers". Chembiochem. 11: 1093–1106. PMC 2873112 Freely accessible. PMID 20419721. doi:10.1002/cbic.200900671.
  4. ↑ Lopez-Gallego, F.; Wawrzyn, G.T.; Schmidt-Dannert, C. (2010). "Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis". Appl. Environ. Microbiol. 76: 7723–7733. PMC 2988597 Freely accessible. PMID 20889795. doi:10.1128/aem.01811-10.
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