Beta-carotene 15,15'-dioxygenase

Beta-carotene 15,15'-dioxygenase (EC 1.13.11.63, blh (gene)) is an enzyme with systematic name beta-carotene:oxygen 15,15'-dioxygenase (bond-cleaving).^[1]^[2] This enzyme catalyses the following chemical reaction

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Beta-carotene 15,15'-dioxygenase contains Fe²⁺.

References

↑ Kim, Y.S.; Kim, N.H.; Yeom, S.J.; Kim, S.W.; Oh, D.K. (2009). "In vitro characterization of a recombinant Blh protein from an uncultured marine bacterium as a β-carotene 15,15′-dioxygenase". J. Biol. Chem. 284: 15781–15793. PMC 2708875 . PMID 19366683. doi:10.1074/jbc.M109.002618.
↑ Kim, Y.S.; Park, C.S.; Oh, D.K. (2010). "Retinal production from β-carotene by β-carotene 15,15′-dioxygenase from an unculturable marine bacterium". Biotechnol. Lett. 32 (7): 957–961. PMID 20229064. doi:10.1007/s10529-010-0239-3.

Oxidoreductases: monooxygenases (EC 1.13)
1.13.11: two atoms of oxygen	lipoxygenase: Arachidonate 5-lipoxygenase Arachidonate 12-lipoxygenase/ALOX12 Arachidonate 8-lipoxygenase Arachidonate 15-lipoxygenase/ALOX15 Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase Homogentisate 1,2-dioxygenase Cysteine dioxygenase 4-Hydroxyphenylpyruvate dioxygenase Indoleamine 2,3-dioxygenase Chlorite dismutase
1.13.12: one atom of oxygen	Firefly luciferase
1.13.99: other	Inositol oxygenase

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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