Basophilic stippling
Basophilic stippling a.k.a. punctate basophilia refers to observing a blood smear in which erythrocytes display small dots at the periphery. These dots are the visualization of ribosomes and can often be found in the peripheral blood smear, even in some normal individuals.[1]
It is associated with several conditions, including:
- Myelodysplastic syndromes
- Sideroblastic anemia[2]
- Lead poisoning (normocytic anemia)[3]
- Arsenic poisoning
- Beta thalassemia (though some have questioned this)[4]
- Alpha thalassemia, HbH Disease
- Hereditary pyrimidine 5'-nucleotidase deficiency
- Thrombotic thrombocytopenic purpura
See also
References
- ↑ Cheson, B. D.; Rom, W. N.; Webber, R. C. (1984). "Basophilic stippling of red blood cells: A nonspecific finding of multiple etiology". American journal of industrial medicine. 5 (4): 327–34. PMID 6202140.
- ↑ "Pathology". Retrieved 2009-02-08.
- ↑ Valentine WN, Paglia DE, Fink K, Madokoro G (October 1976). "Lead poisoning: association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5'-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidines". J. Clin. Invest. 58 (4): 926–32. PMC 333255
. PMID 965496. doi:10.1172/JCI108545. - ↑ Harrington AM, Ward PC, Kroft SH (March 2008). "Iron deficiency anemia, beta-thalassemia minor, and anemia of chronic disease: a morphologic reappraisal". Am. J. Clin. Pathol. 129 (3): 466–71. PMID 18285271. doi:10.1309/LY7YLUPE7551JYBG.
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