BTG4

BTG4

Identifiers

BTG4, PC3B, BTG family member 4, BTG anti-proliferation factor 4, APRO3

External IDs

MGI: 1860140 HomoloGene: 9734 GeneCards: BTG4

Orthologs

Species

Human

Mouse


54766


56057


ENSG00000137707


ENSMUSG00000032056


Q9NY30


O70552

RefSeq (mRNA)


NM_017589


NM_019493

RefSeq (protein)


NP_060059


NP_062366

Location (UCSC)

Chr 11: 111.47 – 111.51 Mb

Chr 9: 51.06 – 51.12 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Protein BTG4 also known as BTG family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4).^[3]^[4] BTG4 has anti-proliferative properties and can induce G₁ cell cycle arrest.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: B-cell translocation gene 4".
1 2 Buanne P, Corrente G, Micheli L, Palena A, Lavia P, Spadafora C, Lakshmana MK, Rinaldi A, Banfi S, Quarto M, Bulfone A, Tirone F (September 2000). "Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium". Genomics. 68 (3): 253–63. PMID 10995567. doi:10.1006/geno.2000.6288.

External links

Human BTG4 genome location and BTG4 gene details page in the UCSC Genome Browser.

Further reading

Auer RL, Starczynski J, McElwaine S, et al. (2005). "Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia.". Genes Chromosomes Cancer. 43 (1): 1–10. PMID 15672409. doi:10.1002/gcc.20159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Dong W, Tu S, Xie J, et al. (2009). "Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer.". Biochem. Biophys. Res. Commun. 387 (1): 132–8. PMID 19576178. doi:10.1016/j.bbrc.2009.06.140.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592–6. PMID 11429045. doi:10.1111/j.1349-7006.2001.tb01135.x.
Toyota M, Suzuki H, Sasaki Y, et al. (2008). "Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.". Cancer Res. 68 (11): 4123–32. PMID 18519671. doi:10.1158/0008-5472.CAN-08-0325.
Tirone F (2001). "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?". J. Cell. Physiol. 187 (2): 155–65. PMID 11267995. doi:10.1002/jcp.1062.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.