BMP2K

BMP2K
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBMP2K, BIKE, HRIHFB2017, BMP2 inducible kinase
External IDsMGI: 2155456 HomoloGene: 34134 GeneCards: BMP2K
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55589

140780

Ensembl

ENSG00000138756

ENSMUSG00000034663

UniProt

Q9NSY1

Q91Z96

RefSeq (mRNA)

NM_017593
NM_198892

NM_080708

RefSeq (protein)

NP_060063
NP_942595

NP_542439

Location (UCSC)Chr 4: 78.78 – 78.92 MbChr 5: 97 – 97.09 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.[3]

Function

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: BMP2K BMP2 inducible kinase".

Further reading

  • Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation". Critical Reviews in Eukaryotic Gene Expression. 11 (1-3): 23–45. PMID 11693963. 
  • Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology. 16 (13): 1338–42. PMID 9853615. doi:10.1038/4315. 
  • Kearns AE, Donohue MM, Sanyal B, Demay MB (Nov 2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro". The Journal of Biological Chemistry. 276 (45): 42213–8. PMID 11500515. doi:10.1074/jbc.M106163200. 
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. PMID 12665801. doi:10.1038/nbt810. 
  • Arikawa T, Omura K, Morita I (Sep 2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells". Journal of Cellular Physiology. 200 (3): 400–6. PMID 15254968. doi:10.1002/jcp.20031. 
  • Medici M, van Meurs JB, Rivadeneira F, Zhao H, Arp PP, Hofman A, Pols HA, Uitterlinden AG (Jun 2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study". Journal of Bone and Mineral Research. 21 (6): 845–54. PMID 16753015. doi:10.1359/jbmr.060306. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026. 


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