BMF (gene)
Bcl-2-modifying factor is a protein that in humans is encoded by the BMF gene.[3][4]
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[4]
Interactions
BMF (gene) has been shown to interact with Bcl-2[3] and DYNLL2.[3][5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 3 Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A (Sep 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–32. PMID 11546872. doi:10.1126/science.1062257.
- 1 2 "Entrez Gene: BMF Bcl2 modifying factor".
- ↑ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (Feb 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. England. 377 (Pt 3): 597–605. PMC 1223895
. PMID 14561217. doi:10.1042/BJ20031251.
External links
- Human BMF genome location and BMF gene details page in the UCSC Genome Browser.
Further reading
- Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357–66. PMID 11214971. doi:10.1093/dnares/7.6.357.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Lei K, Davis RJ (2003). "JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2432–7. PMC 151358 . PMID 12591950. doi:10.1073/pnas.0438011100.
- Day CL, Puthalakath H, Skea G, et al. (2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands.". Biochem. J. 377 (Pt 3): 597–605. PMC 1223895 . PMID 14561217. doi:10.1042/BJ20031251.
- Morales AA, Olsson A, Celsing F, et al. (2004). "Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells.". Leukemia. 18 (1): 41–7. PMID 14574334. doi:10.1038/sj.leu.2403183.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Chen L, Willis SN, Wei A, et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell. 17 (3): 393–403. PMID 15694340. doi:10.1016/j.molcel.2004.12.030.
- Kuwana T, Bouchier-Hayes L, Chipuk JE, et al. (2005). "BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.". Mol. Cell. 17 (4): 525–35. PMID 15721256. doi:10.1016/j.molcel.2005.02.003.
- Soung YH, Lee JW, Park WS, et al. (2006). "BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.". Pathology. 38 (1): 33–4. PMID 16484005. doi:10.1080/00313020500455811.
- Zhang Y, Adachi M, Kawamura R, et al. (2007). "Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation.". Apoptosis. 11 (8): 1349–57. PMID 16830229. doi:10.1007/s10495-006-8266-1.
- Schmelzle T, Mailleux AA, Overholtzer M, et al. (2007). "Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3787–92. PMC 1820662 . PMID 17360431. doi:10.1073/pnas.0700115104.
- Yoo NJ, Soung YH, Lee SH, et al. (2007). "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas.". Tumori. 93 (2): 195–7. PMID 17557568.
This article is issued from
Wikipedia.
The text is licensed under Creative Commons - Attribution - Sharealike.
Additional terms may apply for the media files.