B-cell prolymphocytic leukemia

B-cell prolymphocytic leukemia
Prolymphocyte
Classification and external resources
Specialty Hematology and oncology
ICD-O M9833/3
MeSH D054403

B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.

It can involve deletions from chromosome 11 and chromosome 13.[1]

It has been suggested that some cases may represent a variant of mantle cell lymphoma.[2]

It has a relatively poor prognosis.[3]

Markers

A case has been described as CD20+, CD22+, and CD5-.[4]

It can also be CD5+.[5]

Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.[6]

Treatment

Splenic irradiation has been used in the treatment.[7]

References

  1. ↑ Lens D, Matutes E, Catovsky D, Coignet LJ (2000). "Frequent deletions at 11q 23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)". Leukemia. 14 (3): 427–30. PMID 10720137. doi:10.1038/sj.leu.2401644.
  2. ↑ Ruchlemer R, Parry-Jones N, Brito-Babapulle V, et al. (May 2004). "B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia". Br. J. Haematol. 125 (3): 330–6. PMID 15086413. doi:10.1111/j.1365-2141.2004.04913.x.
  3. ↑ Del Giudice I, Davis Z, Matutes E, et al. (2006). "IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)". Leukemia. 20 (7): 1231–7. PMID 16642047. doi:10.1038/sj.leu.2404238.
  4. ↑ Yamamoto K, Hamaguchi H, Nagata K, Shibuya H, Takeuchi H (April 1998). "Splenic irradiation for prolymphocytic leukemia: is it preferable as an initial treatment or not?". Jpn. J. Clin. Oncol. 28 (4): 267–9. PMID 9657013. doi:10.1093/jjco/28.4.267.
  5. ↑ "Pathology". Archived from the original on 7 February 2009. Retrieved 2009-01-31.
  6. ↑ Crisostomo RH, Fernandez JA, Caceres W (May 2007). "Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia". Leuk. Res. 31 (5): 699–701. PMID 16997373. doi:10.1016/j.leukres.2006.06.010.
  7. ↑ Nakashima H, Saito B, Ariizumi H, Matsuda I, Nakamaki T, Tomoyasu S (December 2008). "Splenic irradiation as a successful treatment for an elderly patient with B-cell prolymphocytic leukemia". Rinsho Ketsueki. 49 (12): 1619–22. PMID 19110524. doi:10.11406/rinketsu.49.1619.
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