Asoxime chloride

Asoxime chloride
Clinical data

Routes of administration	Intramuscular injection
ATC code	none
Legal status
Legal status	Experimental
Identifiers
IUPAC name 4-carbamoyl-1-[({2-[(E)-(hydroxyimino)methyl]pyridinium-1-yl}methoxy)methyl]pyridinium dichloride
CAS Number	34433-31-3^N
PubChem CID	5484128
ChemSpider	13004322^Y
ChEMBL	CHEMBL33051^Y
Chemical and physical data
Formula	C₁₄H₁₆Cl₂N₄O₃
Molar mass	359.21 g/mol
3D model (JSmol)	Interactive image
SMILES C1=CC=[N+](C(=C1)/C=N/O)COC[N+]2=CC=C(C=C2)C(=O)N.[Cl-].[Cl-]
InChI InChI=1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H^Y Key:QELSIJXWEROXOE-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Asoxime chloride, or more commonly HI-6, is a Hagedorn oxime used in the treatment of organophosphate poisoning.^[1]

References

↑ Cochran, R.; Kalisiak, J.; Küçükkilinç, T.; Radic, Z.; Garcia, E.; Zhang, L.; Ho, K. -Y.; Amitai, G.; Kovarik, Z.; Fokin, V. V.; Sharpless, K. B.; Taylor, P. (2011). "Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging". Journal of Biological Chemistry. 286 (34): 29718–29724. PMC 3191013 . PMID 21730071. doi:10.1074/jbc.M111.264739.

Nerve agent / Organophosphate poisoning	Atropine^# Biperiden Diazepam^# Oximes Obidoxime Pralidoxime see also: Cholinesterase
Barbiturate overdose	Bemegride Ethamivan
Benzodiazepine overdose	Cyprodenate Flumazenil
GHB overdose	Physostigmine SCH-50911
Opioid overdose	Diprenorphine Doxapram Nalmefene Nalorphine Naloxone^# Naltrexone
Reversal of neuromuscular blockade	Sugammadex

Other

Arsenic poisoning	Dimercaprol^# Succimer
Cyanide poisoning	4-Dimethylaminophenol Hydroxocobalamin nitrite Amyl nitrite Sodium nitrite^# Sodium thiosulfate^#
Hydrofluoric acid	Calcium gluconate^#
Methanol / Ethylene glycol poisoning	Primary alcohols: Ethanol Fomepizole
Paracetamol toxicity (Acetaminophen)	Acetylcysteine^# Glutathione Methionine^#
Toxic metals (cadmium lead mercury thallium)	Dimercaprol^# Edetates Prussian blue^#
Other	iodine-131 Potassium iodide Methylthioninium chloride^# oxidizing agent Potassium permanganate Prednisolone/promethazine

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.