Apolipoprotein O

APOO
Identifiers
AliasesAPOO, FAM121B, MIC26, Mic23, My025, Apolipoprotein O
External IDsMGI: 1915566 HomoloGene: 11475 GeneCards: APOO
Orthologs
SpeciesHumanMouse
Entrez

79135

68316

Ensembl

ENSG00000184831

ENSMUSG00000079508

UniProt

Q9BUR5

Q9DCZ4

RefSeq (mRNA)

NM_024122

NM_001199337
NM_001199338
NM_001199339
NM_026673

RefSeq (protein)

NP_077027

NP_001186266
NP_001186267
NP_001186268
NP_080949

Location (UCSC)Chr X: 23.83 – 23.91 MbChr X: 94.37 – 94.42 Mb
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse
ApoO
Identifiers
Symbol ApoO
Pfam PF09769
InterPro IPR019166

Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.[3]

The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.[3]

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (November 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. PMID 16956892. doi:10.1074/jbc.M510861200.

Further reading

This article incorporates text from the public domain Pfam and InterPro IPR019166

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