Deodorant

Roll-on deodorant Rexona "Degree" brand

A deodorant is a substance applied to the body to prevent body odor caused by the bacterial breakdown of perspiration in armpits, feet, and other areas of the body. A subgroup of deodorants, antiperspirants, affect odor as well as prevent sweating by affecting sweat glands.

Antiperspirants are typically applied to the underarms, while deodorants may also be used on feet and other areas in the form of body sprays. In the United States, the Food and Drug Administration classifies and regulates most deodorants as cosmetics, but classifies antiperspirants as over-the-counter drugs.[1]

The first commercial deodorant, Mum, was introduced and patented in the late nineteenth century by an inventor in Philadelphia, Pennsylvania, Edna Murphey.[2] The product was briefly withdrawn from the market in the U.S.,[2] but is currently available at U.S. retailers under the brand Ban.[3] The modern formulation of the antiperspirant was patented by Jules Montenier on January 28, 1941.[4] This formulation was first found in "Stopette" deodorant spray, which Time magazine called "the best-selling deodorant of the early 1950s".[5] Stopette was later eclipsed by many other brands as the 1941 patent expired.

There is a popular myth that deodorant use is linked to breast cancer, but so far no such causal link has been substantiated in research.[6][7]

History

In 1888, the first commercial deodorant, Mum, was developed and patented by a U.S. inventor in Philadelphia, Pennsylvania, Edna Murphey.[2] The small company was bought by Bristol-Myers in 1931 and in the late 1940s, Helen Barnett Diserens developed an underarm applicator based on the newly invented ball-point pen.[8][9] In 1952, the company began marketing the product under the name Ban Roll-On.[8][9][10] The product was briefly withdrawn from the market in the U.S.,[2] but it is once again available at retailers in the U.S. under the brand Ban.[3] In the UK it is sold under the names Mum Solid and Mum Pump Spray.[2] Chattem acquired Ban deodorant brand in 1998[11] and subsequently sold it to Kao Corporation in 2000.[12]

In 1903, the first commercial antiperspirant was Everdry. The modern formulation of the antiperspirant was patented by Jules Montenier on January 28, 1941.[4] This patent addressed the problem of the excessive acidity of aluminum chloride and its excessive irritation of the skin, by combining it with a soluble nitrile or a similar compound.[4] This formulation was first found in "Stopette" deodorant spray, which Time Magazine called "the best-selling deodorant of the early 1950s".[5] "Stopette" gained its prominence as the first and long-time sponsor of the game show What's My Line?, and was later eclipsed by many other brands as the 1941 patent expired.

Between 1942 and 1957 the market for deodorants increased 600 times to become a $70 million market. Deodorants were originally marketed primarily to women, but by 1957 the market had expanded to male users, and estimates were that 50% of men were using deodorants by that date. The Ban Roll-On product led the market in sales.[13]

In the early 1960s, the first aerosol antiperspirant in the marketplace was Gillette's Right Guard, whose brand was later sold to Henkel in 2006.[14] Aerosols were popular because they let the user dispense a spray without coming in contact with the underarm area. By the late 1960s, half of all the antiperspirants sold in the U.S. were aerosols, and continued to grow in all sales to 82% by the early 1970s. However, in the late 1970s two problems arose which greatly changed the popularity of these products. First, in 1977 the Food and Drug Administration (FDA) banned the active ingredient used in aerosols, aluminium zirconium chemicals, due to safety concerns over long term inhalation. Second, the Environmental Protection Agency (EPA) limited the use of chlorofluorocarbon (CFC) propellants used in aerosols due to awareness that these gases can contribute to depleting the ozone layer. As the popularity of aerosols slowly decreased, stick antiperspirants became more popular.

Overview

Stick antiperspirant/deodorant

Human perspiration is largely odorless until it is fermented by bacteria that thrive in hot, humid environments. The human underarm is among the most consistently warm areas on the surface of the human body, and sweat glands provide moisture, which when excreted, has a vital cooling effect. When adult armpits are washed with alkaline pH soap, the skin loses its acid mantle (pH 4.5 - 6), raising the skin pH and disrupting the skin barrier.[15] As many bacteria thrive in this elevated pH environment,[16] this makes the skin susceptible to bacterial colonization.[16] The bacteria feed on the sweat from the apocrine glands and on dead skin and hair cells, releasing trans-3-Methyl-2-hexenoic acid in their waste, which is the primary cause of body odor.[17] Underarm hair wicks the moisture away from the skin and aids in keeping the skin dry enough to prevent or diminish bacterial colonization. The hair is less susceptible to bacterial growth and therefore is ideal for preventing the bacterial odor.[18]

Deodorant

Deodorants are classified and regulated as cosmetics by the U.S. Food and Drug Administration (FDA)[1] and are designed to eliminate odor. Deodorants are often alcohol-based. Alcohol initially stimulates sweating, but may also temporarily kill bacteria. Other active ingredients in deodorants include sodium stearate, sodium chloride and stearyl alcohol. Deodorants can be formulated with other, more persistent antimicrobials such as triclosan that slow bacterial growth or with metal chelant compounds such as EDTA. Deodorants may contain perfume fragrances or natural essential oils intended to mask the odor of perspiration. In the past, deodorants included chemicals such as zinc oxide, acids, ammonium chloride, sodium bicarbonate and formaldehyde, but some of these ingredients were messy, irritating to the skin or even carcinogenic.[19]

Over-the-counter products labeled as "natural deodorant crystal" containing the chemical potassium alum, which contains aluminum, have gained new-found popularity as an alternative health product, in spite of concerns about possible contact dermatitis.[20] A popular alternative to modern commercial deodorants is ammonium alum, which is a common type of alum, also containing aluminum, sold in crystal form and often referred to as a deodorant crystal. It has been used as a deodorant throughout history in Thailand, the Far East, Mexico and other countries.

Vaginal deodorant, in the form of sprays, suppositories and wipes, is often used by women to take away the smell of the vagina. Vaginal deodorants can sometimes cause dermatitis.[21]

Deodorant antiperspirant

Methenamine based antiperspirant for treatment of excessive sweating

Deodorants combined with antiperspirant agents are classified as drugs by the FDA.[1] Antiperspirants attempt to stop or significantly reduce perspiration and thus reduce the moist climate in which bacteria thrive. Aluminium chloride, aluminium chlorohydrate, and aluminium-zirconium compounds, most notably aluminium zirconium tetrachlorohydrex gly and aluminium zirconium trichlorohydrex gly, are frequently used in antiperspirants. Aluminium chlorohydrate and aluminium-zirconium tetrachlorohydrate gly are the most frequent active ingredients in commercial antiperspirants.[22] Aluminium-based complexes react with the electrolytes in the sweat to form a gel plug in the duct of the sweat gland. The plugs prevent the gland from excreting liquid and are removed over time by the natural sloughing of the skin. The metal salts work in another way to prevent sweat from reaching the surface of the skin: the aluminium salts interact with the keratin fibrils in the sweat ducts and form a physical plug that prevents sweat from reaching the skin’s surface. Aluminium salts also have a slight astringent effect on the pores; causing them to contract, further preventing sweat from reaching the surface of the skin.[23] The blockage of a large number of sweat glands reduces the amount of sweat produced in the underarms, though this may vary from person to person. Methenamine in the form of cream and spray is successfully used for treatment of excessive sweating and related to it odour. Antiperspirants are usually better applied before bed.[24]

Form

Deodorants and antiperspirants come in many forms. What is commonly used varies in different countries. In Europe, aerosol sprays are popular, as are cream and roll-on forms. In the United States, solid or gel forms are dominant.

Health effects

After using a deodorant containing zirconium, the skin may develop an allergic, axillary granuloma response.[25] Antiperspirants with propylene glycol, when applied to the axillae, can cause irritation and may promote sensitization to other ingredients in the antiperspirant.[26] Deodorant crystals containing synthetically made potassium alum were found to be a weak irritant to the skin.[20] Alcohol-free deodorant is available for those with sensitive skin. Frequent use of deodorants was associated with blood concentrations of the synthetic musk galaxolide.[27]

Aluminum toxicity

Aluminum is present most often in antiperspirants in the form of aluminum chlorohydrate.[22] Aluminum chlorohydrate is not the same as the compound aluminum chloride, which has been established as a neurotoxin.[28][29][30][31] At high doses, aluminum itself adversely affects the blood–brain barrier, is capable of causing DNA damage, and has adverse epigenetic effects.[28][32]

The Food and Drug Administration, in a monograph dedicated to analysing the safety of deodorants, concluded that "despite many investigators looking at this issue, the agency does not find data from topical and inhalation chronic exposure animal and human studies submitted to date sufficient to change the monograph status of aluminum containing antiperspirants", therefore allowing their use and vowing to keep monitoring the scientific literature.[33] Members of the Scientific Committee on Consumer Safety (Europe) concluded that "due to the lack of adequate data on dermal penetration to estimate the internal dose of aluminium following cosmetic uses, risk assessment cannot be performed."[34]

Breast cancer

The myth that breast cancer is believed to be linked with deodorant use has been widely circulated, and appears to originate from a spam email sent in 1999;[6] however, there is no evidence to support the existence of such a link.[7] One constituent of deodorant products which has given cause for concern are parabens, a chemical additive.[35] According to the American Cancer Society "studies have not shown any direct link between parabens and any health problems, including breast cancer".[35]

Kidney dysfunction

The FDA has "acknowledge[d] that small amounts of aluminium can be absorbed from the gastrointestinal tract and through the skin.", leading to a warning "that people with kidney disease may not be aware that the daily use of antiperspirant drug products containing aluminium may put them at a higher risk because of exposure to aluminium in the product."[33] The agency warns people with kidney dysfunction to consult a doctor before using antiperspirants containing aluminum.[33]

Aerosol burns and frostbite

If aerosol deodorant is held close to the skin for long enough, it can cause an aerosol burn—a form of frostbite.[36][37] In controlled tests, spray deodorants have been shown to cause temperature drops of over 60 °C in a short period of time.[36]

Clothing

Aluminium zirconium tetrachlorohydrex gly, a common antiperspirant, can react with sweat to create yellow stains on clothing.[38] Underarm liners are an alternative to antiperspirants that do not leave stains.[39][40]

See also

References

  1. 1 2 3 Cosmetics Q&A: "Personal Care Products". U.S. Food and Drug Administration.
  2. 1 2 3 4 5 Joey Green (2004). "The Apothecary: Elixiers, Remedies, and Tonics". Joey Green's Incredible Country Store: Potions, Notions and Elixirs of the Past--and How to Make Them Today (1 ed.). Rodale Books. p. 356. ISBN 1-57954-848-2.
  3. 1 2 "Chattem acquires Ban deodorant brand". Nashville Business Journal. March 2, 1998.
  4. 1 2 3 US 2230084
  5. 1 2 "Corporations: Scalping the Competition". Time magazine. July 12, 1963.
  6. 1 2 Gorski D (October 6, 2014). "Breast cancer myths: No, antiperspirants do not cause breast cancer". Science-Based Medicine.
  7. 1 2 Namer M, Luporsi E, Gligorov J, Lokiec F, Spielmann M (September 2008). "[The use of deodorants/antiperspirants does not constitute a risk factor for breast cancer]". Bull Cancer (Comprehensive literature review) (in French). 95 (9): 871–80. PMID 18829420. doi:10.1684/bdc.2008.0679 (inactive 2017-01-31).
  8. 1 2 Digest, Editors at Reader's (June 2, 2015). 99 Cent Solutions. Readers Digest. p. 152. ISBN 9781621452386. Retrieved June 11, 2015.
  9. 1 2 Socol, Garrett (December 5, 2011). Gathered Here Together. Ampersand Books. p. 62. ISBN 9780984102587. Retrieved June 11, 2015.
  10. "Advertising and Marketing News". New York Times. January 25, 1955. Retrieved June 12, 2015.
  11. "CHATTEM ACQUIRING BAN BRAND FOR $165 MILLION". The New York Times. February 24, 1998.
  12. "CHATTEM AGREES TO SELL BAN DEODORANT LINE TO JERGENS". The New York Times. August 25, 2000.
  13. Hammer, Alexander R. News (November 23, 1957). "Newest Forms for Deodorants Spur Sales to the Male Market". New York Times. Retrieved June 12, 2015.
  14. "Right Guard". BriefingMedia Ltd.
  15. Kuehl BL, Fyfe KS, Shear NH (March 2003). "Cutaneous cleansers". Skin Therapy Lett. 8 (3): 1–4. PMID 12858234.
  16. 1 2 Stenzaly-Achtert S, Schölermann A, Schreiber J, Diec KH, Rippke F, Bielfeldt S (May 2000). "Axillary pH and influence of deodorants". Skin Res Technol. 6 (2): 87–91. PMID 11428948. doi:10.1034/j.1600-0846.2000.006002087.x.
  17. Pierce JD Jr; Zeng XN; Aronov EV; Preti G; Wysocki CJ (August 1995). "Cross-adaptation of sweaty-smelling 3-methyl-2-hexenoic acid by a structurally similar, pleasant-smelling odorant". Chem Senses. 20 (4): 401–11. PMID 8590025. doi:10.1093/chemse/20.4.401.
  18. Marc Paye; Howard I. Maibach; André O Barel (2009). Handbook of cosmetic science and technology (3 ed.). Informa Health Care. p. 703; 869. ISBN 1-4200-6963-2.
  19. Deodorants & Antiperspirants: Fighting sweat and its odor for more than a century, Chemical Engineering News
  20. 1 2 Gallego H, Lewis EJ, Crutchfield CE 3rd (July 1999). "Crystal deodorant dermatitis: irritant dermatitis to alum-containing deodorant". Cutis. 64 (1): 65–6. PMID 10431678.
  21. "FPA Health: Sex Matters: Factsheets: The Vagina - Common Vaginal Conditions". 31 July 2003. Archived from the original on 28 February 2007.
  22. 1 2 Lukacs VA, Korting HC (1989). "Antitranspirantien und Deodorantien – Wirkstoffe und Bewertung" [Antiperspirants and deodorants – ingredients and evaluation]. Dermatosen in Beruf Und Umwelt (in German). 37 (2): 53–57. PMID 2656175.
  23. Draelos ZD (September 2001). "Antiperspirants and the hyperhidrosis patient". Dermatol Ther. 14 (3): 220–224. doi:10.1046/j.1529-8019.2001.01028.x.
  24. http://www.huffingtonpost.com/2014/08/28/antiperspirant-mistake_n_5701736.html
  25. Kleinhans D, Knoth W (July 1976). "[Granulomas of axillae (zirconium?) (author's transl)]". Dermatologica. 152 (3): 161–7. PMID 939343.
  26. Agren-Jonsson S, Magnusson B (1976). "Sensitization to propantheline bromide, trichlorocarbanilide and propylene glycol in an antiperspirant". Contact Dermatitis. 2 (2): 79–80. PMID 1017183. doi:10.1111/j.1600-0536.1976.tb02989.x.
  27. Hutter HP, Wallner P, Hartl W, Uhl M, Lorbeer G, Gminski R, Mersch-Sundermann V, Kundi M (March 2010). "Higher blood concentrations of synthetic musks in women above fifty years than in younger women". Int J Hyg Environ Health. 213 (2): 124–30. PMID 20056483. doi:10.1016/j.ijheh.2009.12.002.
  28. 1 2 He BP, Strong MJ (January 2000). "A morphological analysis of the motor neuron degeneration and microglial reaction in acute and chronic in vivo aluminum chloride neurotoxicity". J. Chem. Neuroanat. 17 (4): 207–15. PMID 10697247. doi:10.1016/S0891-0618(99)00038-1.
  29. Zubenko GS, Hanin I (October 1989). "Cholinergic and noradrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus". Brain Res. 498 (2): 381–4. PMID 2790490. doi:10.1016/0006-8993(89)91121-9.
  30. Peng JH, Xu ZC, Xu ZX, et al. (August 1992). "Aluminum-induced acute cholinergic neurotoxicity in rat". Mol. Chem. Neuropathol. 17 (1): 79–89. PMID 1388451. doi:10.1007/BF03159983.
  31. Banks, W. A.; Kastin, A. J. (1989). "Aluminum-induced neurotoxicity: alterations in membrane function at the blood–brain barrier". Neurosci Biobehav Rev. 13 (1): 47–53. PMID 2671833. doi:10.1016/S0149-7634(89)80051-X.
  32. Lankoff A, Banasik A, Duma A, et al. (February 2006). "A comet assay study reveals that aluminum induces DNA damage and inhibits the repair of radiation-induced lesions in human peripheral blood lymphocytes". Toxicol. Lett. 161 (1): 27–36. PMID 16139969. doi:10.1016/j.toxlet.2005.07.012.
  33. 1 2 3 "Antiperspirant Drug Products For Over-the-Counter Human Use; Final Monograph". U.S. Food and Drug Administration.
  34. Scientific Committee on Consumer Safety. "OPINION ON the safety of aluminium in cosmetic products" (PDF). Retrieved August 2, 2015.
  35. 1 2 "Antiperspirants and Breast Cancer Risk". American Cancer Society.
  36. 1 2 Ulrich May; Karl-Heinz Stirner; Roger Lauener; Johannes Ring; Matthias Möhrenschlager (2010). "Deodorant spray: a newly identified cause of cold burns". Pediatrics. 126 (3): e716–e718. PMID 20679305. doi:10.1542/peds.2009-2936.
  37. "Deodorant burns on the increase - ABC News". Australian Broadcasting Corporation. July 10, 2007. Retrieved July 1, 2012.
  38. "Mastering The Undershirt". AskMen.com.
  39. Laden, Karl (1999). Anti-Perspirants and Deodorants, Second Edition. CRC Press. ISBN 978-0-8247-1746-9.
  40. Cobb, Linda (2002). How the Queen Cleans Everything. SImon and Schuster. p. 289. ISBN 978-0-7434-5145-1.
Look up deodorant or antiperspirant in Wiktionary, the free dictionary.
Wikimedia Commons has media related to Deodorant.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.