CD79

CD79a molecule, immunoglobulin-associated alpha
Identifiers
Symbol CD79A
Alt. symbols IGA
Entrez 973
HUGO 1698
OMIM 112205
RefSeq NM_001783
UniProt P11912
Other data
Locus Chr. 19 q13.2
CD79b molecule, immunoglobulin-associated beta
Identifiers
Symbol CD79B
Alt. symbols IGB
Entrez 974
HUGO 1699
OMIM 147245
RefSeq NM_021602
UniProt P40259
Other data
Locus Chr. 17 q23

CD79 (Cluster of Differentiation 79) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (formerly known as Ig-alpha and Ig-beta); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding.[1] CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the mb-1 gene that is located on chromosome 19, and CD79b is encoded by the B29 gene that located on chromosome 17.[1][2] Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3-generated signal tranduction observed during T cell receptor activation on T cells.[3]

References

  1. 1 2 Chu P, Arber D (2001). "CD79: a review". Appl Immunohistochem Mol Morphol. 9 (2): 97–106. PMID 11396639. doi:10.1097/00022744-200106000-00001.
  2. ↑ Van Noesel C, Brouns G, van Schijndel G, Bende R, Mason D, Borst J, van Lier R (1992). "Comparison of human B cell antigen receptor complexes: membrane- expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers". J Exp Med. 175 (6): 1511–9. PMC 2119249 Freely accessible. PMID 1375264. doi:10.1084/jem.175.6.1511.
  3. ↑ Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol Lett. 44 (2–3): 97–103. PMID 7541024. doi:10.1016/0165-2478(94)00199-2.


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