Anileridine
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| Clinical data | |
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| AHFS/Drugs.com | Monograph |
| Routes of administration | Tablets, injection |
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| Pharmacokinetic data | |
| Protein binding | > 95% |
| Metabolism | Hepatic |
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| Chemical and physical data | |
| Formula | C22H28N2O2 |
| Molar mass | 352.47 g/mol |
| 3D model (JSmol) | |
| Melting point | 83 °C (181 °F) |
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Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s.[1] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.
Anileridine is no longer manufactured in the US or Canada.[2] Anileridine is in Schedule II of the Controlled Substances Act 1970 of the United States as ACSCN 9020 with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.83 for the dihydrochloride and 0.73 for the phosphate [3] It is also under international control per UN treaties.
Administration
Pharmacokinetics
Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.[5] It is mostly metabolized by the liver.
References
- ↑ U.S. Patent 2,897,204
- ↑ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Retrieved 28 July 2008.
- ↑ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
- ↑ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.
- ↑ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.