Amphipols
Amphipols (a portmanteau of amphiphilic polymers) are a class of polymers and oligomers which are able to keep membrane proteins soluble in water without the need for conventional small molecule surfactants.[1] High molecular weight congeners of amphipols have high affinity for hydrophobic particles.[2]
See also
- Peptitergents - synthetic peptide sequences which can act as detergents for membrane proteins
References
- ↑ Bowie, J (2001). "Stabilizing membrane proteins". Current Opinion in Structural Biology. 11 (4): 397–402. ISSN 0959-440X. doi:10.1016/S0959-440X(00)00223-2.
- ↑ Tribet, C; Audebert, R; Popot, JL (24 December 1996). "Amphipols: polymers that keep membrane proteins soluble in aqueous solutions.". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15047–50. PMC 26353
. PMID 8986761. doi:10.1073/pnas.93.26.15047.
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