Amine oxidase

An amine oxidase is an enzyme that catalyzes the oxidative cleavage of alkylamines into aldehydes and ammonia:^[1]

RCH₂NH₂ + H₂O + O₂

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RCHO + NH₃ + H₂O₂

Amine oxidases are divided into two subfamilies based on the cofactor they contain:

Class	Cofactor	Subclass	Enzyme Commission number	Human genes
Amine oxidase (formerly EC 1.4.3.6)	copper	lysyl oxidase	EC 1.4.3.13	LOX
		primary-amine oxidase	EC 1.4.3.21	AOC2, AOC3
		diamine oxidase	EC 1.4.3.22	AOC1
Monoamine oxidase	flavin	N/A	EC 1.4.3.4	MAOA, MAOB

References

↑ Mondovì B, Finazzi Agrò A (1982). "Structure and function of amine oxidase". Advances in Experimental Medicine and Biology. 148: 141–53. PMID 7124512. doi:10.1007/978-1-4615-9281-5_12.

Amine Oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)

CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)
1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))
1.4.4: disulfide acceptor	Glycine cleavage system
1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase

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