Amgen

Amgen Inc.
Formerly called
Applied Molecular Genetics
(1980–1983)
Public
Traded as NASDAQ: AMGN
NASDAQ-100 Component
S&P 100 Component
S&P 500 Component
SEHK: 4332
Industry Biotechnology
Founded 1980
Headquarters Thousand Oaks, California, U.S.
Key people
Robert A. Bradway
(Chairman, President, and CEO)
Products Epogen, Aranesp, Kineret, Enbrel, Neulasta, Neupogen, Nplate, Vectibix, Prolia, Xgeva, and Sensipar/Mimpara.
Revenue Increase US$22.99 billion (2016)
Increase US$9.79 billion (2016) [1]
Increase US$7.72 billion (2016)
Total assets Increase US$77.63 billion (2016)
Total equity Increase US$29.88 billion (2016)
Number of employees
19,200 (December 2016)[1]
Website www.amgen.com

Amgen Inc. (formerly Applied Molecular Genetics Inc.[2][3]) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotechnology firm. In 2013, the company's largest selling product lines were Neulasta/Neupogen, two closely related drugs used to prevent infections in patients undergoing cancer chemotherapy; and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases. Other products include Epogen, Aranesp, Sensipar/Mimpara, Nplate, Vectibix, Prolia and XGEVA.

History

AMGen corporate logo, 1983
Amgen's corporate Gulfstream V departs Fox Field, Lancaster, California

The word AMGen is a portmanteau of the company's original name, Applied Molecular Genetics, which became the official name of the company in 1983 (three years after incorporation and coincident with its initial public offering). The company's first chief executive officer, from 1980, was co-founder George B. Rathmann, followed by Gordon M. Binder in 1988,[4] followed by Kevin W. Sharer in 2000.[5] Robert A. Bradway became Amgen’s president and chief executive officer in May 2012 following Sharer's retirement.[6]

The company has made at least five major corporate acquisitions.

Timeline

Acquisition timeline

  • 1994 – Synergen, Inc.[27]
  • 2000 – Kinetix Pharmaceuticals, Inc.[28]
  • 2002 – Immunex Corporation[29][30]
  • 2004 – Tularik, Inc.[31]
  • 2006 – Abgenix, Inc.[32][33][34]
  • 2006 – Avidia, Inc.[35]
  • 2007 – Alantos Pharmaceuticals[36]
  • 2007 – Ilypsa, Inc.[37]
  • 2007 – Alantos Pharmaceuticals Holdings, Inc.[37]
  • 2011 – BioVex Group, Inc.[38]
  • 2011 – Laboratório Químico Farmacêutico Bergamo Ltda.[39]
  • 2012 – Micromet, Inc.[40]
  • 2012 – Mustafa Nevzat İlaç[41][42]
  • 2012 – KAI Pharmaceuticals[43]
  • 2012 – deCODE genetics
  • 2013 – Onyx Pharmaceuticals Inc.[44]
  • 2015 – Dezima Pharma[23]
  • 2015 – Catherex[45]

Acquisition history

The following is an illustration of the company's mergers, acquisitions, spin-offs and historical predecessors:

Amgen






















Amgen
(Founded 1983 as Applied Molecular Genetics)






Synergen Inc
(Acq 1994)






Kinetix Pharmaceuticals Inc
(Acq 2000)






Immunex Corporation
(Acq 2002)






Tularik Inc (Acq 2004)






Abgenix Inc
(Acq 2006)






Avidia Inc
(Acq 2006)






Alantos Pharmaceuticals
(Acq 2007)






Ilypsa Inc
(Acq 2007)






Alantos Pharmaceuticals Holdings Inc
(Acq 2007)






BioVex Group Inc
(Acq 2011)






Laboratório Químico Farmacêutico Bergamo Ltda
(Acq 2011)






Micromet Inc
(Acq 2012)






Mustafa Nevzat İlaç
(Acq 2012)






KAI Pharmaceuticals
(Acq 2012)






deCODE genetics
(Acq 2012)






Onyx Pharmaceuticals
(Acq 2013)






NextCODE genetics
(Spun off 2013)






Dezima Pharma
(Acq 2015)






Catherex
(Acq 2015)




Products

As of December, 2013, Amgen had twelve approved drugs or therapeutic biologicals for seventeen conditions (conditions lists are highly generalized; see each article for more detail):

Products developed and then sold off

Pipeline & clinical trials

As of December 2013, Amgen had 11 drugs in Phase III clinical trials.[49]

In November 2014 the company announced it was halting all trials of rilotumumab in advanced gastric cancer patients after one of the trials found more deaths in those who took the compound with chemotherapy, than those without.[50] Later in the same week, the company (in conjunction with AstraZeneca) reported positive results for brodalumab in a phase III trial comparing the compound with ustekinumab and a placebo in treating psoriasis.[51]

In March 2015, the company announced it would license its Phase II candidate drug AMG 714 to developer Celimmune who plan to develop the anti-IL-15 monoclonal antibody for treatment against diet nonresponsive celiac disease and refractory celiac disease.[52]

In June 2015 Amgen presented Phase 2 clinical trial data for their anti-CGRP antibody AMG 334 for migraine.[53]

See also

References

  1. 1 2 "Amgen 2016 SEC Filings 10-K". amgen.com. Retrieved 7 July 2017.
  2. Amgen History official site page accessed January 2, 2016
  3. Ronald Vogel. Pharmaceutical Economics and Public Policy. CRC Press, 2007. ISBN 9781439801345. P. 208
  4. "Amgen, Form 10-K, Annual Report, Filing Date Mar 24, 1998". secdatabase.com. Retrieved Jan 8, 2013.
  5. "Amgen, Form 10-K405, Filing Date Mar 7, 2000". secdatabase.com. Retrieved Jan 8, 2013.
  6. "Amgen, Form 8-K, Current Report, Filing Date May 24, 2012". secdatabase.com. Retrieved Jan 8, 2013.
  7. "Amgen—A biotechnology success story | From drug development to the mass market".
  8. 1 2 "Drugs@FDA: FDA Approved Drug Products".
  9. "Drugs@FDA: FDA Approved Drug Products".
  10. Lyman GH, Kuderer NM, Djulbegovic B (April 2002). "Prophylactic granulocyte colony-stimulating factor in patients receiving dose-intensive cancer chemotherapy: a meta-analysis". Am. J. Med. 112 (5): 406–11. PMID 11904116. doi:10.1016/s0002-9343(02)01036-7.
  11. Chen YF, Jobanputra P, Barton P, et al. (November 2006). "A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness". Health Technol Assess. 10 (42): iii–iv, xi–xiii, 1–229. PMID 17049139. doi:10.3310/hta10420.
  12. Morgan CL, Emery P, Porter D, et al. (January 2014). "Treatment of rheumatoid arthritis with etanercept with reference to disease-modifying anti-rheumatic drugs: long-term safety and survival using prospective, observational data". Rheumatology (Oxford). 53 (1): 186–94. PMID 24140761. doi:10.1093/rheumatology/ket333.
  13. "Drugs@FDA: FDA Approved Drug Products".
  14. "www.accessdata.fda.gov" (PDF).
  15. "FDA approves Xgeva to help prevent cancer-related bone injury".
  16. Terhune, Chad (18 December 2012). "Amgen pleads guilty to improper marketing of anemia drug Aranesp". Los Angeles Times. Retrieved 2 February 2013.
  17. Husten, Larry. "Amgen Pleads Guilty To Misbranding Anemia Drug Aranesp". Forbes. Retrieved 2 February 2013.
  18. "Article > Amgen's Aranesp fails in heart trial, Singapore plant planned".
  19. "Amgen Inc. pleads guilty to federal charge in Brooklyn and pays $762 million to resolve criminal liability and civil fraud allegations" (Press release). Department of Justice  Office of Public Affairs. December 19, 2012. Retrieved 3 October 2013.
  20. Lipton, Eric (19 January 2013). "Fiscal Footnote: Big Senate Gift to Drug Maker". New York Times. Retrieved 2 February 2013.
  21. "Jon Entine: New York Times Mum After Congressional Budget Office Rebukes Bungled Amgen/Medicare Investigation". Huffington Post. 26 February 2013.
  22. "CBO analysis shows keeping oral drugs out of ESRD bundle could save money | Nephrology News & Issues". Archived from the original on 2013-06-05.
  23. 1 2 "For Up to $1.55B, Amgen Acquires Dezima Pharma". GEN.
  24. "Amgen bets up to $1.7B on Xencor's antibody technology". FierceBiotech.
  25. "Amgen, Xencor to Partner on Cancer Immunotherapy, Inflammation Drugs". GEN.
  26. "Amgen Buys Rights to Myeloma BiTE Immunotherapy from Boehringer Ingelheim - GEN News Highlights - GEN".
  27. "Amgen, Form 8-K/A, Filing Date Feb 2, 1995". secdatabase.com. Retrieved Jan 8, 2013.
  28. "Amgen, Form 425, Filing Date Oct 16, 2000". secdatabase.com. Retrieved Jan 8, 2013.
  29. "Amgen, Form 8-K, Current Report, Filing Date Dec 17, 2001". secdatabase.com. Retrieved Jan 8, 2013.
  30. "Amgen - Media - News Release". amgen.com.
  31. "Amgen, Form 8-K, Current Report, Filing Date Mar 29, 2004" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  32. "Amgen, Form 8-K, Current Report, Filing Date Dec 15, 2005" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  33. "Amgen, Form 8-K, Current Report, Filing Date Apr 24, 2006" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  34. "Amgen - Media - News Release". amgen.com.
  35. "Amgen, Form 8-K, Current Report, Filing Date Sep 29, 2006". secdatabase.com. Retrieved Jan 8, 2013.
  36. "Amgen - Media - News Release". amgen.com.
  37. 1 2 "Amgen, Form 10-Q, Quarterly Report, Filing Date Aug 9, 2007" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  38. "Amgen, Form 8-K, Current Report, Filing Date Jan 25, 2011". secdatabase.com. Retrieved Jan 8, 2013.
  39. "Amgen, Form 10-Q, Quarterly Report, Filing Date May 10, 2011" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  40. "Amgen, Form 8-K, Current Report, Filing Date Jan 26, 2012" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  41. "Amgen, Form 8-K, Current Report, Filing Date Apr 30, 2012" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  42. "Türk ilaç devi 700 milyon dolara satýldý". hurriyet.com.tr.
  43. "Amgen, Form 10-Q, Quarterly Report, Filing Date May 8, 2012" (PDF). secdatabase.com. Retrieved Jan 8, 2013.
  44. Guha, Malini (October 8, 2013). "Amgen swallows Onyx whole". Nature Biotechnology. 31: 859–860. PMID 24104731. doi:10.1038/nbt1013-859. Retrieved November 6, 2013.
  45. "Amgen acquires Catherex Spin-off from Medigene - GEN News Highlights - GEN".
  46. Food and Drug Administration December 3, 2014 FDA Press release: Blinatumomab
  47. 1 2 3 Amgen press office. Biovitrum Closes Product Acquisition Deal with Amgen Archived July 3, 2012, at the Wayback Machine.
  48. "Stemgen® (ancestim)". sobi.com.
  49. Amgen Phase III Pipeline, accessed December 29, 2013
  50. "GEN - News Highlights:Amgen Halts Rilotumumab Trials in Advanced Gastric Cancer". GEN.
  51. "GEN - News Highlights:Brodalumab's No Turkey in Phase III: Amgen and AstraZeneca". GEN.
  52. "GEN - News Highlights:Celimmune Licenses Amgen's AMG 714 for Celiac Disease". GEN.
  53. http://www.medscape.com/viewarticle/846893
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