Alphapapillomavirus
| Alphapapillomavirus | |
|---|---|
| Virus classification | |
| Group: | Group I (dsDNA) |
| Family: | Papillomaviridae |
| Genus: | Alphapapillomavirus |
| Type Species | |
| |
Alphapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human and monkeys serve as natural hosts. There are currently 14 species in this genus including the type species Alphapapillomavirus 1. Diseases associated with this genus include: warts, papilloma, malignant tumours. Genital-type, high-risk of malignancy (cervical cancer): HPV-16, 18. Genital-type, low-risk of malignancy (genital warts): HPV-6, 11.[1][2]
Taxonomy
Group: dsDNA
- Family: Papillomaviridae
- Genus: Alphapapillomavirus
- Alphapapillomavirus 1
- Alphapapillomavirus 2
- Alphapapillomavirus 3
- Alphapapillomavirus 4
- Alphapapillomavirus 5
- Alphapapillomavirus 6
- Alphapapillomavirus 7
- Alphapapillomavirus 8
- Alphapapillomavirus 9
- Alphapapillomavirus 10
- Alphapapillomavirus 11
- Alphapapillomavirus 12
- Alphapapillomavirus 13
- Alphapapillomavirus 14
Structure
Viruses in Alphapapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 60 nm. Genomes are circular, around 8kb in length.[1]
| Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
|---|---|---|---|---|---|
| Alphapapillomavirus | Icosahedral | T=7 | Non-enveloped | Circular | Monopartite |
Life cycle
Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. Dna templated transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning, and ribosomal shunting. The virus exits the host cell by nuclear envelope breakdown. Humans and monkeys serve as the natural host. Transmission routes are sexual and contact.[1]
| Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
|---|---|---|---|---|---|---|---|
| Alphapapillomavirus | Humans; monkeys | Epithelial: mucous; epithelial: skin | Cell receptor endocytosis | Lysis | Nucleus | Nucleus | Sex; contact |
References
- 1 2 3 "Viral Zone". ExPASy. Retrieved 12 June 2015.
- 1 2 ICTV. "Virus Taxonomy: 2014 Release". Retrieved 12 June 2015.