Aliskiren/amlodipine

Aliskiren/amlodipine
Combination of
Aliskiren Renin inhibitor
Amlodipine Calcium channel blocker (dihydropyridine)
Clinical data
Trade names Tekamlo
AHFS/Drugs.com Consumer Drug Information
License data
Pregnancy
category
  • C in first trimester
    D in second and third trimesters
Routes of
administration		 Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
 NYesY (what is this?)  (verify)

The drug combination aliskiren/amlodipine (INNs, trade name Tekamlo) is an antihypertensive. Clinical trials have shown it to be more effective than amlodipine on its own,[1] with a high dosing regime (aliskiren 300 mg/amlodipine 10 mg) being more effective than olmesartan/amlodipine with comparable tolerability.[2]

References

  1. ↑ Pfeiffer, Dietrich; Rennie, Nicola; C. Papst, Cheraz; Zhang, Jack (2012). "Efficacy and Tolerability of Aliskiren/Amlodipine Single-Pill Combinations in Patients who did not Respond Fully to Amlodipine Monotherapy". Current Vascular Pharmacology. 10 (6): 773–780. ISSN 1570-1611. doi:10.2174/157016112803520945.
  2. ↑ Axthelm, Christoph; Sieder, Christian; Meister, Franziska; Kaiser, Edelgard (2011). "Efficacy and tolerability of the single-pill combination of aliskiren 300 mg/amlodipine 10 mg in hypertensive patients not controlled by olmesartan 40 mg/amlodipine 10 mg". Current Medical Research and Opinion. 28 (1): 69–78. ISSN 0300-7995. doi:10.1185/03007995.2011.637914.


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